(6CI,7CI)-2-对甲苯萘合成路线 （共 62 条）
参考文献
Syntex Corporation
Patent: US3978116 A1, 1976 ;
反应条件
1: in tetrahydrofuran
T=20°C; Suzuki-Miyaura coupling; 0.0833333 h; Inert atmosphere;
2: With triethyl borane in tetrahydrofuran; hexane
T=20°C; Suzuki-Miyaura coupling; 0.0833333 h; Inert atmosphere;
3: With [Ni0(1,5-cyclooctadiene)2]; tri-cyclo-hexyl-phosphine in tetrahydrofuran; hexane; o-xylene
T=110°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Yu, Da-Gang; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2011 , vol. 50, # 31 p. 7097 - 7100
反应条件
1: in tetrahydrofuran
T=20°C; Suzuki-Miyaura coupling; 0.0833333 h; Inert atmosphere;
2: With triethyl borane in tetrahydrofuran; hexane
T=20°C; Suzuki-Miyaura coupling; 0.0833333 h; Inert atmosphere;
3: With [Ni0(1,5-cyclooctadiene)2]; tri-cyclo-hexyl-phosphine in tetrahydrofuran; hexane; o-xylene
T=110°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Yu, Da-Gang; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2011 , vol. 50, # 31 p. 7097 - 7100
反应条件
1: Ni(PCy3)2Cl2 / toluene / 1 h / 30 °C / Inert atmosphere
2: triethylamine / benzene / Reflux
3: Ni(PCy3)2Cl2 / toluene / 1 h / 30 °C / Inert atmosphere
View Scheme
参考文献
Zhao, Fei; Yu, Da-Gang; Zhu, Ru-Yi; Xi, Zhenfeng; Shi, Zhang-Jie
Chemistry Letters, 2011 , vol. 40, # 9 p. 1001 - 1003
反应条件
1: magnesium / tetrahydrofuran
2: Ni(PCy3)2Cl2 / toluene / 1 h / 30 °C / Inert atmosphere
View Scheme
参考文献
Zhao, Fei; Yu, Da-Gang; Zhu, Ru-Yi; Xi, Zhenfeng; Shi, Zhang-Jie
Chemistry Letters, 2011 , vol. 40, # 9 p. 1001 - 1003
反应条件
1: triethylamine / benzene / Reflux
2: Ni(PCy3)2Cl2 / toluene / 1 h / 30 °C / Inert atmosphere
View Scheme
参考文献
Zhao, Fei; Yu, Da-Gang; Zhu, Ru-Yi; Xi, Zhenfeng; Shi, Zhang-Jie
Chemistry Letters, 2011 , vol. 40, # 9 p. 1001 - 1003
反应条件
1: 3-chloro-benzenecarboperoxoic acid; boron trifluoride diethyl etherate / diethyl ether; dichloromethane
2: trifluoroacetic acid sodium salt / water; dichloromethane
3: 2Na(1+)*H2O*Cl4Pt(2-); tetrabutylammonium trifluoromethanesulphonate / 72 h / 100 °C
View Scheme
参考文献
Wagner, Anna M.; Hickman, Amanda J.; Sanford, Melanie S.
Journal of the American Chemical Society, 2013 , vol. 135, # 42 p. 15710 - 15713
反应条件
in neat (no solvent)
T=150°C; 1 h; Inert atmosphereMicrowave irradiation; Overall yield = 76percent; Overall yield = 83 mg;
参考文献
Castro, Susana; Fernandez, Juan J.; Vicente, Ruben; Fananas, Francisco J.; Rodriguez, Felix
Chemical Communications, 2012 , vol. 48, # 72 p. 9089 - 9091
反应条件
in tetrahydrofuran; toluene
T=110°C; 24 h; Schlenk technique;
参考文献
Uchiyama, Nanase; Shirakawa, Eiji; Hayashi, Tamio
Chemical Communications, 2013 , vol. 49, # 4 p. 364 - 366
反应条件
in tetrahydrofuran; toluene
T=110°C; 0.5 h; Schlenk technique; Overall yield = 22 percent;
参考文献
Uchiyama, Nanase; Shirakawa, Eiji; Hayashi, Tamio
Chemical Communications, 2013 , vol. 49, # 4 p. 364 - 366
