2-(4-氟苯基)环己酮合成路线 （共 11 条）
反应条件
sulfur trioxide pyridine complex; triethylamine in dimethyl sulfoxide
T=0°C; 1.25 h; Product distribution / selectivity;
参考文献
Ceccarelli, Simona Maria; Jolidon, Synese; Pinard, Emmanuel; Thomas, Andrew William
Patent: US2005/154001 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
chloro-trimethyl-silane; copper dichloride; dichloro bis(acetonitrile) palladium(II) in 1,4-dioxane
T=70°C; 10 h;
参考文献
Han, Xiaoqing; Wang, Xiang; Pei, Tao; Widenhoefer, Ross A.
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6333 - 6342
反应条件
trans-[1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene]PdCl2(NC5H5); sodium t-butanolate in tetrahydrofuran
T=70°C; 8 h; Inert atmosphere;
参考文献
Cao, Changsheng; Wang, Lingling; Cai, Zhengyuan; Zhang, Lingqiao; Guo, Jin; Pang, Guangsheng; Shi, Yanhui
European Journal of Organic Chemistry, 2011 , # 8 p. 1570 - 1574
反应条件
magnesium in hydrogenchloride; water; benzene
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4150135 A1, 1979 ;
反应条件
caesium carbonate; bis(phosphinite) PCR-pincer palladacycle; tetraphenyl deriv in N,N-dimethyl-formamide
T=153°C; 1.25 h;
参考文献
Churruca, Fatima; SanMartin, Raul; Tellitu, Imanol; Dominguez, Esther
Tetrahedron Letters, 2006 , vol. 47, # 19 p. 3233 - 3237
反应条件
1: tetrahydrofuran / Heating
2: DMSO; oxalyl chloride / CH2Cl2
3: 81 percent / Me3SiCl; CuCl2 / [PdCl2(CH3CN)2] / dioxane / 10 h / 70 °C
View Scheme
参考文献
Han, Xiaoqing; Wang, Xiang; Pei, Tao; Widenhoefer, Ross A.
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6333 - 6342
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tri-n-butyltin fluoride; triethylamine; [(t-Bu)3PH]BF4 in benzene
T=80°C; 24 h; Inert atmosphere;
参考文献
Beck, Elizabeth M.; Hyde, Alan M.; Jacobsen, Eric N.
Organic Letters, 2011 , vol. 13, # 16 p. 4260 - 4263
反应条件
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane
T=80°C; 24 h;
参考文献
Martinez, Alberto; Webber, Matthew J.; Mueller, Steffen; List, Benjamin
Angewandte Chemie - International Edition, 2013 , vol. 52, # 36 p. 9486 - 9490
Angew. Chem., 2013 , vol. 125, # 36 p. 9664 - 9668,5
反应条件
1: CuBr*Me2S / tetrahydrofuran / 0 °C
2: aq. Dess-Martin periodinane / CH2Cl2 / 20 °C
View Scheme
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
反应条件
1: CuBr*Me2S / tetrahydrofuran / 0 °C
2: aq. Dess-Martin periodinane / CH2Cl2 / 20 °C
View Scheme
参考文献
Pinard, Emmanuel; Ceccarelli, Simona M.; Stalder, Henri; Alberati, Daniela
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 349 - 353
