6-甲氧基-1H-苯并三唑-5-羧酸合成路线 （共 6 条）
反应条件
1: H2 / Pd/C
2: NaNO2, aq. HCl
3: aq. NaOH
View Scheme
参考文献
Hirokawa, Yoshimi; Yamazaki, Hiroshi; Yoshida, Naoyuki; Kato, Shiro
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1973 - 1978
反应条件
1: HNO3
2: H2 / Pd/C
3: NaNO2, aq. HCl
4: aq. NaOH
View Scheme
参考文献
Hirokawa, Yoshimi; Yamazaki, Hiroshi; Yoshida, Naoyuki; Kato, Shiro
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1973 - 1978
参考文献
Hirokawa, Yoshimi; Yamazaki, Hiroshi; Yoshida, Naoyuki; Kato, Shiro
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1973 - 1978
反应条件
1: NaNO2, aq. HCl
2: aq. NaOH
View Scheme
参考文献
Hirokawa, Yoshimi; Yamazaki, Hiroshi; Yoshida, Naoyuki; Kato, Shiro
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1973 - 1978
反应条件
hydrogenchloride in water
T=80°C; hydrolysis constants by the action of 1M NaOH(aq.), t0.5, other temperatures, ΔG(excit.); Thermodynamic dataKineticsRate constant;
参考文献
Hoffmann; Jacobi
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 12 p. 1714 - 1715
反应条件
thionyl chloride in methanol
4 h; Reflux;
参考文献
Aprile, Silvio; Del Grosso, Erika; Grosa, Giorgio
Journal of Mass Spectrometry, 2012 , vol. 47, # 6 p. 737 - 750
