2,3-二氨基-5-溴-6-甲基吡啶合成路线 （共 8 条）
反应条件
1: aqueous HCl; NaNO2 2: palladium/charcoal; platinum; aq. NaOH solution / Hydrogenation View Scheme
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
参考文献
Yutilov; Svertilova; Minkina; Kirillova; Smolyar
Russian Journal of Applied Chemistry, 2005 , vol. 78, # 5 p. 787 - 790
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
in 1-methyl-pyrrolidin-2-one T=140°C; 120 h; Inert atmosphere;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; CHERUVALLATH, Zacharia; KOMANDLA, Mallareddy; LAWSON, John David; MCBRIDE, Christopher; TANG, Mingnam
Patent: WO2014/39831 A1, 2014 ;
Location in patent: Paragraph 0151-0152 ;
反应条件
hydrogenchloride; sodium nitrite
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
hydrazine hydrate; zinc in butan-1-ol
Heating;
参考文献
Yutilov; Svertilova; Minkina; Kirillova; Smolyar
Russian Journal of Applied Chemistry, 2005 , vol. 78, # 5 p. 787 - 790
反应条件
1: HNO3; H2SO4 / 0 - 60 °C
2: 90 percent / hydrazine hydrate; Zn / butan-1-ol / Heating
View Scheme
参考文献
Yutilov; Svertilova; Minkina; Kirillova; Smolyar
Russian Journal of Applied Chemistry, 2005 , vol. 78, # 5 p. 787 - 790
反应条件
1: 25 g / Br2; AcONa; AcOH / 1 h / 15 °C
2: HNO3; H2SO4 / 0 - 60 °C
3: 90 percent / hydrazine hydrate; Zn / butan-1-ol / Heating
View Scheme
参考文献
Yutilov; Svertilova; Minkina; Kirillova; Smolyar
Russian Journal of Applied Chemistry, 2005 , vol. 78, # 5 p. 787 - 790
