1,2,3,4-四氢-4-(2-羟基苯基)-6-甲基-2-氧代-5-嘧啶羧酸乙酯合成路线 （共 8 条）
参考文献
Bartalini
P.Groth, Chemische Krystallographie 5.Teil <Leipzig 1919> S. 833
反应条件
Wells-Dawson heteropolyacid catalyst
T=80°C; Biginelli reaction; 1.5 h;
参考文献
Shockravi, Abbas; Kamali, Mahmood; Sharifi, Negar; Nategholeslam, Mahdieh; Moghanlo, Somayeh Pahlavan
Synthetic Communications, 2013 , vol. 43, # 11 p. 1477 - 1483
反应条件
piperidine in ethanol
4 h; Heating;
参考文献
Kumar, Baldev; Kaur, Balbir; Kaur, Jatinder; Parmar, Anupama; Anand; Kumar, Harish
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 7 p. 1526 - 1530
反应条件
1: 2-hydroxymethyl-phenol With Bi(NO3)3 in various solvent(s)
T=50°C; 0.0833333 h;
2: ethyl acetoacetate; urea in various solvent(s)
T=90°C;
参考文献
Khosropour, Ahmad R.; Khodaei, Mohammd M.; Beygzadch, Mojtaba; Jokar, Mahbubeh
Heterocycles, 2005 , vol. 65, # 4 p. 767 - 773
反应条件
Bi(NO3)3
T=100°C; Biginelli reaction; 0.416667 h;
参考文献
Khosropour, Ahmad R.; Khodaei, Mohammad M.; Beygzadeh, Mojtaba
Heteroatom Chemistry, 2007 , vol. 18, # 6 p. 684 - 687
反应条件
Bi(NO3)3*ZnCl2*Al2O3
T=140°C; 0.333333 h; microwave irradiation;
参考文献
Singh, Jagjeet; Koui, Summon; Pannu, Ajay P. S.; Sharma, Rattan L.; Razdan, Tej K.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 2 p. 349 - 357
反应条件
hydrogenchloride in ethanol; water
T=140°C; 0.05 h; Microwave irradiation;
参考文献
Kshirsagar; Nimje; Chaudhari; Oswal
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1713 - 1715
反应条件
1: hydrogenchloride / water / 2.5 h / 70 °C / |Green chemistry
2: hydrogenchloride / ethanol; water / 2 h / |Reflux; |Green chemistry
View Scheme
参考文献
Liu, Qingjian; Xu, Jiehua; Teng, Fei; Chen, Anjun; Pan, Ning; Zhang, Wenwen
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 3 p. 741 - 746
