sodium hydroxide in ethanol 1 h; Heating;

1: oxyde de diphenylphosphinomethylephenylcetone With sodium methylate in tetrahydrofuran T=20°C; 0.25 h; 2: α-bromoacetophenone in tetrahydrofuran T=20°C; 27 h; Further stages.;

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine in tetrahydrofuran T=20°C; 0.0833333 h;

1.1: n-BuLi / tetrahydrofuran / 0.25 h / 0 °C 1.2: 62 percent / tetrahydrofuran / 3 h / -78 °C 2.1: NaOMe / tetrahydrofuran / 0.25 h / 20 °C 2.2: 86 percent / tetrahydrofuran / 27 h / 20 °C View Scheme

1.1: n-BuLi / tetrahydrofuran / 0.25 h / 0 °C 1.2: 62 percent / tetrahydrofuran / 3 h / -78 °C 2.1: NaOMe / tetrahydrofuran / 0.25 h / 20 °C 2.2: 86 percent / tetrahydrofuran / 27 h / 20 °C View Scheme