4-羟基-1-(3-吡啶基)-1-丁酮合成路线 （共 10 条）
反应条件
n-butyllithium Acylation;
参考文献
Vo-Thanh, Giang; Felpin, Francois-Xavier; Nourrisson, Gilbert; Trierweiler, Michel; Robins, Richard J.; Lebreton, Jacques
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 13 p. 881 - 888
反应条件
pH 8 sodium phosphate buffer in water T=37°C; 96 h; Further byproducts given;
参考文献
Journal of the American Chemical Society, , vol. 108, # 6 p. 1292 - 1295
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP234729 B1, 1991 ;
EP 0234729 B1
反应条件
1: 3-bromo-pyridine With n-butyllithium in diethyl ether; hexane T=-78 - 20°C; Inert atmosphere; 2: tetrahydrofuran-2-one in diethyl ether; hexane T=-78 - 20°C; Inert atmosphere; regioselective reaction;
参考文献
Synthesis, , # 1 p. 91 - 97
反应条件
hydrogen; boric acid; nickel in methanol; water 20 h; Ambient temperature;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 41, p. 426 - 434
反应条件
cytochrome P450 reductase pH=7; aq. phosphate bufferEnzymatic reaction;
参考文献
Journal of the American Chemical Society, , vol. 133, # 5 p. 1459 - 1465
反应条件
human gastric juice; sodium nitrite T=37°C; 0.5 h; Product distribution; Further Variations:Reagents;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 48, # 2 p. 392 - 394
反应条件
1.1: 82 percent / (COCl)2; NEt3 / dimethylsulfoxide 2.1: molecular sieves 4 Angstroem / CH2Cl2 / 16 h / 20 °C 2.2: 45 percent / NaCNBH3 / methanol; acetic acid / 16 h / 0 - 20 °C 3.1: 95 percent / aq. HCl; methanol View Scheme
参考文献
Loh, Teck-Peng; Zhou, Jian-Rong; Li, Xu-Ran; Sim, Keng-Yeow
Tetrahedron Letters, 1999 , vol. 40, # 44 p. 7847 - 7850
反应条件
1: sodium tetrahydroborate / methanol / 2 h / 0 °C 2: [{(η5-C5Me5)IrCl}2(μ-Cl)2]; sodium carbonate / water / 2 h / 110 °C / |Inert atmosphere; |Microwave irradiation; |Green chemistry View Scheme
参考文献
Apsunde, Tushar Dattu; Trudell, Mark L.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2012-M0987-S, p. 2120 - 2124
反应条件
oxalyl dichloride; triethylamine in dimethyl sulfoxide
Oxidation; Swern oxidation;
参考文献
Loh, Teck-Peng; Zhou, Jian-Rong; Li, Xu-Ran; Sim, Keng-Yeow
Tetrahedron Letters, 1999 , vol. 40, # 44 p. 7847 - 7850
