2-氨基-4-氯甲基噻唑盐酸盐合成路线 （共 14 条）
反应条件
in isopropyl alcohol T=20 - 40°C; Inert atmosphere; Product distribution / selectivity;
参考文献
REPLIDYNE, INC.
Patent: WO2009/15193 A1, 2009 ;
Location in patent: Page/Page column 44 ;
WO 2009/015193 A1
参考文献
Lundina,I.B.; Postovskii,I.Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967 , vol. 3, p. 201 - 204
Khimiya Geterotsiklicheskikh Soedinenii, 1967 , vol. 3, p. 266 - 269
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: EP224919 B1, 1991 ;
参考文献
Klayman; Grenan; Jacobus
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 510 - 512
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2008/86047 A1, 2008 ;
Location in patent: Page/Page column 153-154 ;
WO 2008/086047 A1
反应条件
triethylamine in 1,4-dioxane T=2 - 20°C; 144 h; Product distribution / selectivity;
参考文献
REPLIDYNE, INC.
Patent: WO2008/11191 A1, 2008 ;
Location in patent: Page/Page column 36-37 ;
WO 2008/011191 A1
参考文献
Kumar, Yatendra; Green, Rachel; Wise, Dean S.; Wotring, Linda L.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3849 - 3852
反应条件
1: With hydrogenchloride; copper(II) sulfate; sodium nitrite in water T=0 - 20°C; 1.25 h; 2: With hydrogenchloride; copper(l) chloride in water T=20°C; 0.0833333 h; 3: With ammonia in diethyl ether; water
参考文献
WYETH
Patent: WO2008/73929 A1, 2008 ;
Location in patent: Page/Page column 112 ;
WO 2008/073929 A1
参考文献
Lundina,I.B.; Postovskii,I.Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967 , vol. 3, p. 201 - 204
Khimiya Geterotsiklicheskikh Soedinenii, 1967 , vol. 3, p. 266 - 269
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 3, p. 201 - 204
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 3, p. 266 - 269
