ammonia; sodium methylate; potassium iodide in methanol T=5°C; electrooxidation;

potassium carbonate; isobutyraldehyde

toluene-4-sulfonic acid T=190°C; 0.0833333 h; Neat (no solvent)Microwave irradiationClosed vessel;

暂无反应条件数据

暂无反应条件数据

暂无反应条件数据

1: p-TsOH*H2O / benzene / 8 h / Heating 2: 64 percent / PCC, NaOAc / CH2Cl2 / 12 h / Ambient temperature 3: 2.) Jones reagent / 1.) ether, 12 h at r.t.; 2.) acetone, 30 min at 0 deg C 4: 1.) LiAlH4; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t. 5: 99 percent / mCPBA / CH2Cl2 / 12 h / Ambient temperature 6: 1.) NaOMe; 2.) Collins reagent / 1.) benzene, 2 d at r.t.; 2.) CH2Cl2, 2 h at r.t. 7: 95 percent / LiAlH(OtBu)3 / diethyl ether / 1 h / -78 °C 8: 93 percent / NaH / benzene / 2 h / Heating 9: 92 percent / 3 N HCl / acetone / 5 h / Heating 10: 85 percent / diethyl ether / 12 h / Ambient temperature 11: 73 percent / Na / liquid ammonia / 0.33 h / -78 °C View Scheme

1.1: potassium carbonate; water; hydroxylamine hydrochloride / ethanol / 48 h / 70 °C / |Cooling with ice 2.1: trifluoroacetic anhydride / -15 °C / |Reflux 3.1: methanol / 16 h / 25 °C 4.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C 4.2: -78 - 25 °C 5.1: methanol; water; hydrogenchloride / 1 h / 55 °C 6.1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 0.25 h / 25 °C View Scheme

1: K2CO3 / ethanol; H2O 2: HN(SiMe3)2, Py View Scheme

pyridine; 1,1,1,3,3,3-hexamethyl-disilazane