2-溴-2-甲基丙酸乙酯合成路线 （共 239 条）
反应条件
in further solvent(s)
activation of Zn (5 percent HCl), washing (water, acetone, ether), addn. of alkene bromide (in dimethoxymethane);
参考文献
Cui, Hua; Li, Ying; Zhang, Songlin
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 14 p. 2862 - 2869
反应条件
1: 1.) Zn, 3.) 20percent aq.NH4Cl / 1.) dimethoxymethane, 2.) dimethoxymethane, room temp., 10 min.
2: 90 percent / m-chloroperbenzoic acid / CHCl3 / 3 h / 0 °C
View Scheme
参考文献
De Blic, Arnaud; Cazaux, Louis; Gorrichon-Guigon, Liliane; Perry, Marcel
Synthesis, 1982 , # 4 p. 281 - 283
反应条件
ammonium chloride; zinc
1.) dimethoxymethane, 2.) dimethoxymethane, room temp., 10 min.; Yield given. Multistep reaction;
参考文献
De Blic, Arnaud; Cazaux, Louis; Gorrichon-Guigon, Liliane; Perry, Marcel
Synthesis, 1982 , # 4 p. 281 - 283
反应条件
1: 2-amino-5-nitro-phenol With potassium fluoride in N,N-dimethyl-formamide
T=20°C; 1 h;
2: ethyl 2-bromo-2-methyl propionate in N,N-dimethyl-formamide
T=60°C; 20.33 h;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2007/89034 A1, 2007 ;
Location in patent: Page/Page column 73 ;
WO 2007/089034 A1
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=50 - 60°C; 6 h;
参考文献
Shridhar; Gandhi Rao
Synthesis, 1982 , vol. No. 11, p. 986 - 987
反应条件
diethyl ether; magnesium; benzene
参考文献
Jacques; Horeau
Bulletin de la Societe Chimique de France, 1948 , p. 711,715
反应条件
1: magnesium; diethyl ether; benzene
2: formic acid / 100 °C
View Scheme
参考文献
Jacques; Horeau
Bulletin de la Societe Chimique de France, 1948 , p. 711,715
反应条件
T=160°C; Behandeln der Reaktionsprodukte mit waessr. Kalilauge und mit alkoh. Kalilauge;
参考文献
Bischoff
Chemische Berichte, 1900 , vol. 33, p. 1675
参考文献
Blaise; Courtot
Bulletin de la Societe Chimique de France, 1906 , vol. <3> 35, p. 367,370
反应条件
1: With zinc in tetrahydrofuran
Reformatsky-type reaction;
2: With hydrogenchloride in tetrahydrofuran
参考文献
Fuerstner, Alois; Mathes, Christian; Lehmann, Christian W.
Chemistry - A European Journal, 2001 , vol. 7, # 24 p. 5299 - 5317
