2-溴-2-甲基丙酸乙酯合成路线 （共 239 条）
反应条件
Man verseift das erhaltene Estergemisch mit Kalilauge, erhitzt die in Freiheit gesetzten Saeuren auf 200grad und destilliert, kocht die bei 270-290grad siedende Fraktion mit Wasser;
参考文献
Bischoff
Chemische Berichte, 1890 , vol. 23, p. 3395
Full Text Show Details
Bischoff; Jaunsnicker
Chemische Berichte, 1890 , vol. 23, p. 3400
参考文献
Dippy; Parkins
Journal of the Chemical Society, 1951 , p. 1570,1573
反应条件
zinc in 1,4-dioxane; diethyl ether Substitution; 0.166667 h; Heating; Title compound not separated from byproducts;
参考文献
Fotin; Shchepin; Vakhrin
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 9 p. 1278 - 1281
参考文献
Villieras,J. et al.
Journal of Organometallic Chemistry, 1975 , vol. 102, p. 129 - 140
参考文献
Cason; Fessenden
Journal of Organic Chemistry, 1957 , vol. 22, p. 1326,1332
参考文献
Hussey; Newman
Journal of the American Chemical Society, 1948 , vol. 70, p. 3024,3025
参考文献
Cason; Fessenden
Journal of Organic Chemistry, 1957 , vol. 22, p. 1326,1332
参考文献
Kahovec; Kohlrausch
Monatshefte fuer Chemie, 1943 , vol. 74, p. 115
反应条件
1: 4-hydroxy-benzonitrile With potassium carbonate in acetonitrile 1 h; Heating / reflux; 2: ethyl 2-bromo-2-methyl propionate With potassium carbonate 72 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/49578 A1, 2005 ;
Location in patent: Page/Page column 59 ;
WO 2005/049578 A1
反应条件
caesium carbonate in DMF (N,N-dimethyl-formamide) T=60°C;
参考文献
KALYPSYS, INC.
Patent: WO2004/92117 A1, 2004 ;
Location in patent: Page 51 ;
WO 2004/092117 A1
