2-氯-4-(三氟甲基)苯乙酸合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 1 h;
参考文献
ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon
Patent: WO2013/14587 A1, 2013 ;
Location in patent: Page/Page column 63-64 ;
WO 2013/014587 A1
反应条件
n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; Pd2dba3 in toluene
参考文献
Signal Pharmaceuticals, Inc.
Patent: US6620838 B1, 2003 ;
反应条件
in dichloromethane
T=20°C; 7 h;
参考文献
MERCK SHARP and DOHME LIMITED; HOLLINGWORTH, Gregory, John; JONES, A., Brian; SPAREY, Timothy, Jason
Patent: WO2005/49613 A1, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/049613 A1
反应条件
1: (1,2,3,4,5-pentaphenylferrocen-1'-yl)-di-tert-butylphosphine; bis(dibenzylideneacetone)-palladium(0) / tetrahydrofuran; diethyl ether / 6 h / 70 °C / |Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon
Patent: WO2013/14587 A1, 2013 ;
WO 2013/014587 A1
