2-甲基-3-羟基苯甲酸合成路线 （共 39 条）
反应条件
1: H2SO4 2: Br2 3: K2CO3 View Scheme
参考文献
Cresp,T.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 2435 - 2447
反应条件
1: H2SO4 2: Br2 3: K2CO3 4: aq. NaOH / methanol View Scheme
参考文献
Cresp,T.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 2435 - 2447
反应条件
1: H2SO4 2: Br2 3: K2CO3 View Scheme
参考文献
Cresp,T.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 2435 - 2447
反应条件
1: sulfuric acid / Inert atmosphere; Reflux 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 1 h / Inert atmosphere; Reflux View Scheme
参考文献
Tang, Ying; Wei, Zhenhong; Zhong, Wei; Liu, Xiaoming
European Journal of Inorganic Chemistry, 2011 , # 7 p. 1112 - 1120
反应条件
1: 3-hydroxy-2-methyl-benzoic acid With sodium hydroxide in water T=40°C; pH=5.5 - 10.5; 2: dimethyl sulfate With sodium hydroxide in water T=40 - 45°C; pH=10.4 - 10.6; 4 h; 3: With sodium hydroxide; sulfuric acid more than 3 stages;
参考文献
Bayer Aktiengesellschaft
Patent: EP1371626 A2, 2003 ;
Location in patent: Page 7, 8 ;
反应条件
1: 100 percent / hydrogen chloride / Heating 2: 72 percent / K2CO3 / acetone / Heating 3: 100 percent / LiAlH4 / diethyl ether / 20 °C View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1: 3-hydroxy-2-methyl-benzoic acid With sodium hydroxide in water pH=6.9; 2: acetic anhydride With sodium hydroxide T=0 - 5°C; pH=8.8 - 9.2; 4 h; 3: With hydrogenchloride T=5°C; pH=3.8 - 4.2;
参考文献
Bayer Aktiengesellschaft
Patent: EP1371625 A1, 2003 ;
Location in patent: Page 7 ;
反应条件
hydrogenchloride; sodium hydroxide in water; acetic anhydride
参考文献
Clariant GmbH
Patent: US5910605 A1, 1999 ;
反应条件
sulfuric acid T=20 - 44°C; 2 h;
参考文献
AGOURON PHARMACEUTICALS, INC.; JAPAN TOBACCO INC.
Patent: EP1361216 A1, 2003 ;
Location in patent: Page/Page column 22-23 ;
反应条件
methyllithium; calcium carbonate
参考文献
Kalle and Co.
Patent: DE91201 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 149
