3-(4-溴苯基)-3-(3-吡啶基)烯丙胺合成路线 （共 16 条）
反应条件
hydrazine hydrate in methanol
T=60°C; 5 h;
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: tetrahydrofuran / 5 h / 60 °C
2: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
3: 41 percent / dimethylformamide / 3 h / 80 °C
4: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: 76 percent / LiAlH4 / diethyl ether / 5 h / Heating
2: PBr3 / CH2Cl2 / Heating
3: H2O / 4 h / Ambient temperature
4: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
5: 41 percent / dimethylformamide / 3 h / 80 °C
6: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: 51 percent / 1.) BuLi / diethyl ether; hexane / 1.) -60 deg C, 1 h, 2.) -40 to -30 deg C, 50 min, 3.) to room temperature, 2.5 h
2: conc. H2SO4, Ac2O / 0.5 h / Heating
3: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
4: 41 percent / dimethylformamide / 3 h / 80 °C
5: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: 51 percent / 1.) BuLi / diethyl ether; hexane / 1.) -60 deg C, 1 h, 2.) -40 to -30 deg C, 50 min, 3.) to room temperature, 2.5 h
2: conc. H2SO4, Ac2O / 0.5 h / Heating
3: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
4: 41 percent / dimethylformamide / 3 h / 80 °C
5: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: formic acid, water / 3 h / Heating
2: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
3: 41 percent / dimethylformamide / 3 h / 80 °C
4: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: conc. H2SO4, Ac2O / 0.5 h / Heating
2: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
3: 41 percent / dimethylformamide / 3 h / 80 °C
4: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: PCl5 / CH2Cl2
2: 41 percent / dimethylformamide / 3 h / 80 °C
3: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
2: 41 percent / dimethylformamide / 3 h / 80 °C
3: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
反应条件
1: H2O / 4 h / Ambient temperature
2: 70 percent / ClCOOCH2CCl3 / benzene / 2 h / Heating
3: 41 percent / dimethylformamide / 3 h / 80 °C
4: 1.25 g / H2NNH2*H2O / methanol / 5 h / 60 °C
View Scheme
参考文献
Carnmalm; De Paulis; Hogberg; et al.
1982 , vol. 36, # 2 B p. 91 - 99
