1-苄基-4-羟基哌啶-4-羧酸甲酯合成路线 （共 6 条）
参考文献
Nagai; Maki; Kanda; Natsuka; Umemoto
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 6 p. 1179 - 1188
反应条件
1: 1-benzyl-4-hydroxy-piperidine-4-carbonitrile With hydrogenchloride; water
T=90°C; 1 h;
2: methanol With sulfuric acid
T=50°C; 1 h;
参考文献
AiCuris GMBH and Co. KG
Patent: US2010/22527 A1, 2010 ;
Location in patent: Page/Page column 16 ;
US 20100022527 A1
反应条件
hydrogenchloride in methanol; water
18 h; Heating / reflux;
参考文献
Zheng, Guo Zhu; Brown, Brian S.; Turner, Sean C.; White, Tammie K.; Schmidt, Robert G.; Koenig, John R.; Lee, Chih-Hung
Patent: US2005/80095 A1, 2005 ;
Location in patent: Page/Page column 20 ;
反应条件
1: sodium disulfide / H2O / 1 h / 0 °C
2: HCl / diethyl ether / 4 °C
View Scheme
参考文献
Tsukamoto, Shin-ichi; Ichihara, Masato; Wanibuchi, Fumikazu; Usuda, Shinji; Hidaka, Kazuyuki; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2292 - 2299
反应条件
1: 1-Phenylmethyl-piperidin-4-one; trimethylsilyl cyanide With zinc(II) iodide in dichloromethane
18 h; Heating / reflux;
2: With hydrogenchloride
T=20°C; 30 h;
3: methanol With hydrogenchloride
1 h; Cooling with ice;
参考文献
G.D. SEARLE and CO.
Patent: EP1221441 A2, 2002 ;
Location in patent: Page 201-202 ;
反应条件
1: With 5 palladium on charcoal; hydrogen in methanol; acetic acid
P=2585.81 Torr; 2 h;
2: With di-tert-butyl dicarbonate in methanol; acetic acid
参考文献
THE GENERAL HOSPITAL CORPORATION; ANNOVATION BIOPHARMA, LLC; RAINES, Douglas, E.; HUSAIN, Syed Shaukat; RANDLE, John, C.R.
Patent: WO2013/106717 A1, 2013 ;
Location in patent: Paragraph 00207 ;
