2,3-二甲氧基-5-甲基-1,4-苯醌合成路线 （共 103 条）
反应条件
(NH4)2S2O8; silver nitrate in water; acetonitrile
T=65°C; 3.5 h;
参考文献
Ma, Wei; Zhou, Hao; Ying, Yi-Lun; Li, Da-Wei; Chen, Guo-Rong; Long, Yi-Tao; Chen, Hong-Yuan
Tetrahedron, 2011 , vol. 67, # 33 p. 5990 - 6000
反应条件
1: 90 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 0.67 h
2: 82 percent / NaOH / ethanol; H2O / 0.75 h / Ambient temperature
3: 78 percent / HCl / H2O / 40 °C
4: 84 percent / CAN / acetonitrile; H2O / 1 h / 0 °C
5: 1.) Cp2ZrCl2, 2.) NiCl2, PPh3, n-BuLi / 1.) ClCH2CH2Cl, 0 deg C, 2.) THF, hexane. -78 deg C, 30 min, -78 deg C to 0 deg C, 1.75 h
View Scheme
参考文献
Lipshutz, Bruce H.; Kim, Sung-Kyu; Mollard, Paul; Stevens, Kirk L.
Tetrahedron, 1998 , vol. 54, # 7 p. 1241 - 1253
反应条件
boron trifluoride diethyl etherate; silver(l) oxide
Yield given. Multistep reaction;
参考文献
Naruta
Journal of Organic Chemistry, 1980 , vol. 45, # 21 p. 4097 - 4104
反应条件
boron trifluoride diethyl etherate; silver(l) oxide
Yield given. Multistep reaction;
参考文献
Naruta
Journal of Organic Chemistry, 1980 , vol. 45, # 21 p. 4097 - 4104
反应条件
(NH4)2S2O8; silver nitrate in water; acetonitrile
T=65°C; 3.5 h;
参考文献
Ma, Wei; Zhou, Hao; Ying, Yi-Lun; Li, Da-Wei; Chen, Guo-Rong; Long, Yi-Tao; Chen, Hong-Yuan
Tetrahedron, 2011 , vol. 67, # 33 p. 5990 - 6000
反应条件
1: aq. Na2S2O3 / diethyl ether
3: aq. FeCl3 / diethyl ether
View Scheme
参考文献
Koshi,K.; Shimizu,M.
Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, p. 2343 - 2350
反应条件
hydrogen iodide
T=60°C; 24 h;
参考文献
Sasaki, Toru; Maekawa, Satoshi; Ishii, Shin-ichi; Senda, Michio
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 40, p. 687 - 688
反应条件
1: 99 percent / AcOH / 24 h / 20 °C
2: t-BuOK / tetrahydrofuran; dimethylformamide / 2 h / -25 °C
3: 12.64 g / 4 h / 100 °C / 6 Torr
4: aq. Na2S2)4 / acetone / 0.5 h / 20 °C
View Scheme
参考文献
Wang, Guangyang
Journal of the American Chemical Society, 1998 , vol. 120, # 8 p. 1657 - 1664
反应条件
in N,N-dimethyl-formamide
T=-23°C; 3 h;
参考文献
Araki, Shuki; Katsumura, Nobuhito; Butsugan, Yasuo
Journal of Organometallic Chemistry, 1991 , vol. 415, # 1 p. 7 - 24
反应条件
1: 99 percent / AcOH / 24 h / 20 °C
2: t-BuOK / tetrahydrofuran; dimethylformamide / 2 h / -25 °C
3: 12.64 g / 4 h / 100 °C / 6 Torr
View Scheme
参考文献
Merz; Rauschel
Synthesis, 1993 , # 8 p. 797 - 802
