2-氨基-3-硝基苯甲酸合成路线 （共 76 条）
反应条件
hydrogenchloride; sodium sulfide; copper diacetate 1.) H2O, MeOH, reflux, 2.) EtOH; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: NaOH; hydrazine hydrate; Raney Ni 2: K3Fe(CN)6 / methanol / Heating View Scheme
参考文献
Xue, Fei; Luo, Xianjin; Ye, Chenghao; Ye, Weidong; Wang, Yue
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2641 - 2649
反应条件
1: 66 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr
2: 20 percent / PPA / 1 h / 150 - 160 °C
3: SOCl2 / tetrahydrofuran; dimethylformamide / 20 °C
4: conc. aq. NH3 / tetrahydrofuran; dimethylformamide
View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: diethyl ether
2: H2 / Pd(OH)2/C / methanol / 760 Torr
3: BH3*pyridine / methanol / 20 °C
View Scheme
参考文献
Beaulieu, Pierre L.; Boes, Michael; Bousquet, Yves; Fazal, Gulrez; Gauthier, Jean; Gillard, James; Goulet, Sylvie; LaPlante, Steven; Poupart, Marc-Andre; Lefebvre, Sylvain; McKercher, Ginette; Pellerin, Charles; Austel, Volkhard; Kukolj, George
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 119 - 124
参考文献
Chapman; Stephen
Journal of the Chemical Society, 1925 , vol. 127, p. 1794
反应条件
sodium dithionite in ethanol; water
T=70°C; 24 h;
参考文献
Kaerkaes, Markus D.; Akermark, Torbjoern; Johnston, Eric V.; Karim, Shams R.; Laine, Tanja M.; Lee, Bao-Lin; Akermark, Tobias; Privalov, Timofei; Akermark, Bjoern
Angewandte Chemie - International Edition, 2012 , vol. 51, # 46 p. 11589 - 11593
Angew. Chem., 2012 , vol. 124, # 46 p. 11757 - 11761,5
反应条件
borane-THF in tetrahydrofuran
T=0 - 30°C; 1 h; Inert atmosphere;
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
bromine; acetic acid
参考文献
English et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 295,301, 2265
参考文献
English et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 295,301, 2265
参考文献
Huntress; Gladding
Journal of the American Chemical Society, 1942 , vol. 64, p. 2644,2646
