2,2-二乙氧基乙酸乙酯合成路线 （共 88 条）
参考文献
Anderson, Kjell; Fischer, Alan Eric; Ioannidis, Panagiotis; Larsson, Magnus; Larsson, Maria; Sivadasan, Sivaprasad
Patent: US2003/139474 A1, 2003 ;
参考文献
Mylo
Chemische Berichte, 1911 , vol. 44, p. 3214
反应条件
1: With toluene-4-sulfonic acid T=90°C; 27 h; 2: With phosphorus pentoxide T=90 - 100°C; 2 h;
参考文献
Dannhardt, Gerd; Gruchalla, Markus V.; Kohl, Beate K.; Parsons
Archiv der Pharmazie, 2000 , vol. 333, # 8 p. 267 - 274
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Kraemer, Irene; Schunack, Walter
Archiv der Pharmazie (Weinheim, Germany), 1986 , vol. 319, # 12 p. 1091 - 1098
反应条件
P2O5; toluene-4-sulfonic acid 1.) 90 deg C, 27 h, 2.) 90 -100 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Hook, James M.; Road, Lensfield
Synthetic Communications, 1984 , vol. 14, # 1 p. 83 - 88
反应条件
in tetrahydrofuran T=-78°C; 2 h;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Synthetic Communications, 2002 , vol. 32, # 20 p. 3199 - 3205
反应条件
1: acetyl chloride; iodine 2: 150 °C 3: potassium tert-butylate / toluene View Scheme
参考文献
Deussen, Heinz-Josef; Zundel, Magali; Valdois, Marine; Lehmann, Soren Vig; Weil, Volker; Mailand Hjort, Carsten; stergaard, Peter Rahbek; Marcussen, Erik; Ebdrup, Soren
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 82 - 88
反应条件
sodium hydride in benzene
参考文献
Baker; Huang; Meyer Jr.
Journal of medicinal chemistry, 1968 , vol. 11, # 3 p. 475 - 482
反应条件
boron trifluoride diethyl etherate in chloroform 1.5 h; Heating / reflux;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2005/99705 A2, 2005 ;
Location in patent: Page/Page column 48 ;
反应条件
air 1.) CHCl3, 1 h, 2.) 72 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Russian Journal of Organic Chemistry, , vol. 33, # 9 p. 1346 - 1350
