反应条件
1: methyl malonic acid diethylester With sodium hydride in N,N-dimethyl-formamide
T=0 - 5°C; Inert atmosphere;
2: 2-bromo-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-one in N,N-dimethyl-formamide
T=-3°C; Inert atmosphere;
3: With hydrogenchloride in water; N,N-dimethyl-formamide
pH=4 - 5; Inert atmosphere;
参考文献
Caldwell, Richard D.; GUCKIAN, Kevin M.; KUMARA VEL, Gnanasambandam; LEE, Wen-Cherng; LIN, Edward Yin-Shiang; LlU, Xiaogao; MA, Bin; SCOTT, Daniel M.; SHl, Zhan; THOMAS, Jermaine; TAVERAS, Arthur G.; ZHENG, Guo Zhu
Patent: US2014/100195 A1, 2014 ;
Location in patent: Page/Page column ;
