顺式-1,2-二羟甲基乙烯合成路线 （共 151 条）
反应条件
manganese(IV) oxide in dichloromethane 48 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Wei, Xudong; Taylor, Richard J. K.
Tetrahedron Letters, 1998 , vol. 39, # 22 p. 3815 - 3818
反应条件
1H-imidazole in N,N-dimethyl-formamide
参考文献
Abraham, Elin; Davies, Stephen G.; Millican, Nicholas L.; Nicholson, Rebecca L.; Roberts, Paul M.; Smith, Andrew D.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 9 p. 1655 - 1664
反应条件
toluene-4-sulfonic acid in cyclohexane Heating;
参考文献
Frauenrath, Herbert; Philipps, Thomas
Tetrahedron, 1986 , vol. 42, # 4 p. 1135 - 1138
反应条件
1: cis-1,4-dihydroxy-2-butene With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 2: benzyl bromide in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David
Patent: WO2012/67663 A1, 2012 ;
Location in patent: Page/Page column 60 ;
反应条件
1: cis-1,4-dihydroxy-2-butene With sodium hydride in tetrahydrofuran T=0 - 20°C; 1 h; Inert atmosphere; 2: benzyl chloride in tetrahydrofuran T=0 - 20°C; 24 h;
参考文献
Dayde, Benedicte; Pierra, Claire; Gosselin, Gilles; Surleraux, Dominique; Ilagouma, Amadou Tidjani; Laborde, Coralie; Volle, Jean-Noel; Virieux, David; Pirat, Jean-Luc
European Journal of Organic Chemistry, 2014 , vol. 2014, # 6 p. 1333 - 1337
反应条件
hydrogen; Montmorillonite-Ph2PPd(II) in tetrahydrofuran T=25°C; P=760 Torr; 2 h; other catalysts (Lindlar catalyst); no solvent; at 50 deg C; Product distribution;
参考文献
Chickos, James S.; Uang, Jack Y.-J.; Keiderling, Tim A.
Journal of Organic Chemistry, 1991 , vol. 56, # 7 p. 2594 - 2596
反应条件
hydrogen; ruthenium palladium in propan-1-ol T=89.9°C; Rate constant;
参考文献
Karavanov, A. N.; Gryaznov, V. M.; Batyrev, I. G.; Olenina, E. G.
Russian Journal of Physical Chemistry, 1995 , vol. 69, # 5 p. 739 - 743
Zhurnal Fizicheskoi Khimii, 1995 , vol. 69, # 5 p. 816 - 821
反应条件
phosphorus tribromide in diethyl ether T=-20 - -5°C; 2 h;
参考文献
Synthetic Communications, , vol. 21, # 5 p. 721 - 726
反应条件
pyridine; diphosphinidenecyclobutene-coordinated palladium in toluene T=100°C; 6 h;
参考文献
Murakami, Hiromi; Matsui, Yukio; Ozawa, Fumiyuki; Yoshifuji, Masaaki
Journal of Organometallic Chemistry, 2006 , vol. 691, # 14 p. 3151 - 3156
反应条件
pyridine; thionyl chloride in diethyl ether 1.) 0 deg C, 2.5 h, 2.) r.t., overnight;
参考文献
Ravikumar, Vasulinga T.; Cheruvallath, Zacharia S.; Cole, Douglas L.
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6643 - 6646
Title/Abstract Full Text View citing articles Show Details
Ravikumar, Vasulinga T.; Cheruvallath, Zacharia S.; Cole, Douglas L.
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1709 - 1712
