4,4-二甲基-2,6-二氧代哌啶-3,5-二甲腈合成路线 （共 19 条）
反应条件
reagiert entsprechend mit Methylaethylketon, Cyclohexanon, 1-Methyl-cyclohexanon-(3) und 1-Methyl-cyclohexanon-(4);
参考文献
Thorpe; Wood
Journal of the Chemical Society, 1913 , vol. 103, p. 1575
Journal of the Chemical Society, 1923 , vol. 123, p. 63
参考文献
Thorpe; Wood
Journal of the Chemical Society, 1913 , vol. 103, p. 1575
Journal of the Chemical Society, 1923 , vol. 123, p. 63
反应条件
1: 97 percent / H2SO4, H2O
2: 92 percent / H2SO4 / toluene
3: 79 percent / sodium / toluene / 28 h
4: 87 percent / 85 percent phosphoric acid / Heating
5: 79 percent / LiAlH4 / diethyl ether / 22 h / Heating
View Scheme
参考文献
Holder, Richard W.; Daub, John P.; Baker, Wesley E.; Gilbert, Raymond H; Graf, Norman A.
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1445 - 1451
反应条件
1: aqueous acetic acid
2: aqueous KOH
View Scheme
参考文献
Ramberg; Wideqvist
Arkiv foer Kemi, 1941 , vol. 14 B, # 37 p. 4,11, 12
反应条件
sulfuric acid
T=120 - 140°C;
参考文献
Schoen, Uwe; Antel, Jochen; Brueckner, Reinhard; Messinger, Josef; Franke, Rainer; Gruska, Andreas
Journal of Medicinal Chemistry, 1998 , vol. 41, # 3 p. 318 - 331
反应条件
1: aqueous acetic acid
2: aqueous KOH
3: aqueous NaOH
View Scheme
参考文献
Ramberg; Wideqvist
Arkiv foer Kemi, 1941 , vol. 14 B, # 37 p. 4,11, 12
反应条件
1: aq. H2SO4
2: aq. H2SO4
3: LiAlH4 / diethyl ether
View Scheme
参考文献
Handley,G.J. et al.
Australian Journal of Chemistry, 1960 , vol. 13, p. 129 - 144
参考文献
Ramberg; Wideqvist
Arkiv foer Kemi, 1941 , vol. 14 B, # 37 p. 4,11, 12
反应条件
1: 97 percent / H2SO4, H2O
2: 92 percent / H2SO4 / toluene
3: 79 percent / sodium / toluene / 28 h
4: 87 percent / 85 percent phosphoric acid / Heating
5: 79 percent / LiAlH4 / diethyl ether / 22 h / Heating
6: 48 aq. HBr, conc. sulfuric acid / 48 h / 25 °C
7: 83 percent / quninoline / 150 - 195 °C
View Scheme
参考文献
Holder, Richard W.; Daub, John P.; Baker, Wesley E.; Gilbert, Raymond H; Graf, Norman A.
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1445 - 1451
