三苯基-(3,4,5-三甲氧基-苄基)-溴化膦合成路线 （共 26 条）
反应条件
sodium hydride in benzene 16 h; Ambient temperature;
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Chakraborti, Asit K.; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2579 - 2588
反应条件
1: 3,4,5-Trimethoxybenzyltriphenylphosphonium Bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: (4-methoxyphenyl)methanol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 12 h; Inert atmosphereReflux; optical yield given as percent de;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
in tetrahydrofuran
24 h; Heating;
参考文献
Olszewski; Marshalla; Sabat; Sundberg
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4285 - 4296
反应条件
1: CBr4; triphenylphosphine / acetone / 20 °C
2: 17.64 g / toluene / 2 h / Heating
View Scheme
参考文献
Ramirez, Daniel A.; Zhang, Jianxing; Klausmeyer, Kevin; Kane, Robert R.
Journal of Chemical Crystallography, 2005 , vol. 35, # 3 p. 227 - 232
参考文献
Nussbaumer, Peter; Winiski, Anthony P.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 16 p. 7552 - 7560
反应条件
1: NaBH4 / methanol / 20 °C
2: PBr3 / diethyl ether / -40 °C
3: benzene / 20 °C
View Scheme
参考文献
Maya, Ana B. S.; Perez-Melero, Concepcion; Mateo, Carmen; Alonso, Dulce; Fernandez, Jose Luis; Gajate, Consuelo; Mollinedo, Faustino; Pelaez, Rafael; Caballero, Esther; Medarde, Manuel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 556 - 568
反应条件
1: 3,4,5-trimethoxy-benzaldehyde With sodium tetrahydroborate in ethanol
T=20°C; 2 h;
2: dibromotriphenyl-phosphorane in acetonitrile
T=90°C; 6 h;
参考文献
Das, Bhaskar C.; Mahalingam, Sakkarapalayam M.; Evans, Todd
Tetrahedron Letters, 2009 , vol. 50, # 25 p. 3031 - 3034
反应条件
in acetone
8 h; Inert atmosphere;
参考文献
Tanpure, Rajendra P.; Strecker, Tracy E.; Chaplin, David J.; Siim, Bronwyn G.; Trawick, Mary Lynn; Pinney, Kevin G.
Journal of Natural Products, 2010 , vol. 73, # 6 p. 1093 - 1101
反应条件
1: 3,4,5-trimethoxy-benzyl alcohol With phosphorus tribromide in dichloromethane
T=-5°C; 0.75 h;
2: triphenylphosphine in toluene
T=20°C; 24 h;
参考文献
Falciani, Chiara; Brunetti, Jlenia; Pagliuca, Chiara; Menichetti, Stefano; Vitellozzi, Lucia; Lelli, Barbara; Pini, Alessandro; Bracci, Luisa
ChemMedChem, 2010 , vol. 5, # 4 p. 567 - 574
反应条件
1: lithium borohydride / methanol / 20 °C
2: phosphorus tribromide / benzene / 20 °C
3: toluene / 120 °C
View Scheme
参考文献
Parihar, Swati; Kumar, Amit; Chaturvedi, Amit K.; Sachan, Naresh Kumar; Luqman, Suaib; Changkija, Bendangla; Manohar, Murli; Prakash, Om; Chanda; Khan, Feroz; Chanotiya; Shanker, Karuna; Dwivedi, Anila; Konwar, Rituraj; Negi, Arvind S.
Journal of Steroid Biochemistry and Molecular Biology, 2013 , vol. 137, p. 332 - 344
