2-甲基-10H-苯并[b]噻吩并[2,3-e][1,4]二氮杂革-4-胺合成路线 (共 5 条)
反应条件
in propan-1-ol T=110°C; Heating / reflux; Product distribution / selectivity;
参考文献
Apotex Pharmachem Inc.
Patent: US2008/319189 A1, 2008 ;
Location in patent: Page/Page column 2 ;
反应条件
in 1-methyl-pyrrolidin-2-one; toluene
参考文献
INKE, S.A.
Patent: WO2007/77134 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
hydrogenchloride in isopropyl alcohol
参考文献
Hryhorenko, Eric; Sankaran, Banumathi; DeCory, Thomas R.; Tubbs, Theresa; Colt, Linda; Remmerie, Bart M.; Salter, Rhys; Donahue, Matthew Garrett; Gong, Yong
Patent: US2014/57303 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: potassium hydroxide / dimethyl sulfoxide
2: ethyl acetate
3: hydrogenchloride / isopropyl alcohol
View Scheme
参考文献
Hryhorenko, Eric; Sankaran, Banumathi; DeCory, Thomas R.; Tubbs, Theresa; Colt, Linda; Remmerie, Bart M.; Salter, Rhys; Donahue, Matthew Garrett; Gong, Yong
Patent: US2014/57303 A1, 2014 ;
反应条件
1: ethyl acetate
2: hydrogenchloride / isopropyl alcohol
View Scheme
参考文献
Hryhorenko, Eric; Sankaran, Banumathi; DeCory, Thomas R.; Tubbs, Theresa; Colt, Linda; Remmerie, Bart M.; Salter, Rhys; Donahue, Matthew Garrett; Gong, Yong
Patent: US2014/57303 A1, 2014 ;