(S)-(-)-1-苯基-1-丙醇合成路线 （共 162 条）
反应条件
1: sodium carbonate / water / 72 h / 28 °C / pH 9 2: yeast strain Rhodotorula glutinis H93 / |Microbiological reaction View Scheme
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 102, p. 94 - 98
反应条件
1: 97 percent / pyridine, 4-(dimethylamino)pyridine / Ambient temperature 2: 1) KF, KHCO3, 2) 30percent H2O2 / 1) THF, MeOH, 2) THF, MeOH, 60 deg C, 15 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 25 p. 7076 - 7083
反应条件
potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate 1) THF, MeOH, 2) THF, MeOH, 60 deg C, 15 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 56, # 25 p. 7076 - 7083
反应条件
1: sodium iodide / diethyl ether / 48 h / Reflux 2: [(R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine](p-cymene)ruthenium; formic acid; triethylamine / ethyl acetate / 168 h / 20 °C / Inert atmosphere View Scheme
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 67, # 6 p. 717 - 721
反应条件
sodium hydroxide; dihydrogen peroxide; (-)-Monoisopinocampheylborane 1.) THF, -25 deg C, 24 h, 2.) 55 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 47, # 26 p. 5074 - 5083
反应条件
methanol; sodium hydroxide; diisopinocamphenylboron chloride; dihydrogen peroxide 1.) a.) THF, -25 deg C, 72 h, b.) 0 deg C, 24 h, 2.) 55 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 47, # 26 p. 5065 - 5069
反应条件
(1R,2R,4S)-2-Me2NCH2C6H4-1,3,3-Me3-bicyclo[2.2.1]heptan-2-ol in hexane T=6°C; Condensation; 24 h; Product distribution; Further Variations:ReagentsTemperatures;
参考文献
Journal of Organic Chemistry, , vol. 65, # 1 p. 77 - 82
反应条件
in 2,2,4-trimethylpentane T=40°C; 0.5 h; Molecular sieveEnzymatic reaction; optical yield given as percent ee;
参考文献
Preparative Biochemistry and Biotechnology, , vol. 40, # 4 p. 389 - 404
反应条件
in 2,2,4-trimethylpentane T=60°C; 0.0833333 h; Microwave irradiationEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Preparative Biochemistry and Biotechnology, , vol. 40, # 4 p. 389 - 404
反应条件
(+)-PhCD(OH)Et in benzene Ambient temperatureother alkyllithium; multistep reaction; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 111, # 18 p. 7265 - 7266
