(9CI)-2-(1,1-二甲基乙基)-嘧啶合成路线 （共 9 条）
反应条件
bromine; sodium acetate in acetic acid T=80°C; 3 h;
参考文献
Heterocycles, , vol. 31, # 1 p. 109 - 114
反应条件
sodium hydroxide; sulfur in methanol
T=170°C; 12 h;
参考文献
Pews, Richard Garth
Heterocycles, 1990 , vol. 31, # 1 p. 109 - 114
反应条件
palladium/alumina
T=320 - 350°C;
参考文献
Pews, Richard Garth
Heterocycles, 1988 , vol. 27, # 8 p. 1867 - 1872
参考文献
Wang, Tiansheng; Cloudsdale, Ian S.
Synthetic Communications, 1997 , vol. 27, # 14 p. 2521 - 2526
反应条件
sodium methylate in methanol
T=150°C; 12 h; other temperatures; addition of various inhibitors; other halogenopyrimidine; Product distributionMechanism;
参考文献
Pews, Richard Garth
Heterocycles, 1990 , vol. 31, # 1 p. 109 - 114
反应条件
1: 1.) 225 deg C; 2.) o-xylene, reflux, 48 h,
2: 80 percent / 0.5percent Pd/Al2O3 / 320 - 350 °C
View Scheme
参考文献
Pews, Richard Garth
Heterocycles, 1988 , vol. 27, # 8 p. 1867 - 1872
反应条件
aluminum oxide; palladium/alumina
91.3 h; 1) 275 deg C, 2) 320 deg C; Further byproducts given. Title compound not separated from byproducts;
参考文献
Hull, John W.; Otterson, Kari
Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2925 - 2929
反应条件
aluminum oxide; palladium/alumina
T=275 - 320°C; 91.3 h; other acid, other catalyst, other conditions; MechanismProduct distribution;
参考文献
Hull, John W.; Otterson, Kari
Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2925 - 2929
反应条件
1: 60 percent / bromine, sodium acetate / acetic acid / 3 h / 80 °C
2: 58 percent / sodium methoxide / methanol / 12 h / 150 °C / other temperatures; addition of various inhibitors; other halogenopyrimidine
View Scheme
参考文献
Pews, Richard Garth
Heterocycles, 1990 , vol. 31, # 1 p. 109 - 114
