2'-溴-4'-甲基乙酰苯胺合成路线 （共 38 条）
反应条件
potassium carbonate; palladium diacetate in N,N-dimethyl-formamide
T=130°C; 30 h;
参考文献
Cui, Xin; Li, Juan; Fu, Yao; Liu, Lei; Guo, Qing-Xiang
Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3458 - 3462
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 84 percent / 2 h / Heating
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
oxygen; anhydrous cobalt diacetate; sodium bromide in acetic acid
T=100°C; 1.33333 h; var. concentration of reagents; Product distribution;
参考文献
Shcherbina, F. F.; Tmenov, D. N.; Lysukho, T. V.; Belous, N. P.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, p. 340 - 342
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 2 p. 381 - 384
反应条件
1: sodium hydroxide; hydrogenchloride / water
2: bromine / acetic acid / 1 h / 5 - 20 °C
View Scheme
参考文献
Bhagat; Deshmukh; Kuberkar
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 4 p. 873 - 876
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 80percent NaH / tetrahydrofuran / 48 h / Heating; further reagent: BuLi
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 80percent NaH / tetrahydrofuran / 48 h / Heating; further reagent: BuLi
4: 22 percent / BuLi / tetrahydrofuran; hexane / -70 deg C to r.t., 20 h
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
phase transfer procedure;
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 62 percent / toluene / Heating
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 6 percent / pTosOH / toluene / 2 h / Heating
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
反应条件
1: 91 percent / phase transfer procedure
2: 60 percent / KOH / methanol / 12 h / Heating
3: 6 percent / pTosOH / toluene / 2 h / Heating
4: 1) tBuLi, 2) aq. NH4Cl / 1) THF, pentane, -100 deg C, 2) THF, pentane, r.t.
View Scheme
参考文献
Hellwinkel, Dieter; Laemmerzahl, Frank; Hofmann, Gunter
Chemische Berichte, 1983 , vol. 116, # 10 p. 3375 - 3405
