1: With potassium carbonate in N,N-dimethyl-formamide
T=20 - 80°C; 1 - 7 h;
2: With hydrogenchloride; water in N,N-dimethyl-formamide
Product distribution / selectivity;
1: pyridine / 4 h / 120 °C / |Reflux
2: sodium hydride; water / N,N-dimethyl-formamide; mineral oil / 17 h / 0 - 20 °C
3: dichloromethane / 1.5 h / 0 °C
View Scheme
参考文献
Bazin, Marc-Antoine; Bodero, Lizeth; Tomasoni, Christophe; Rousseau, Benedicte; Roussakis, Christos; Marchand, Pascal
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 823 - 832