2-溴己酸合成路线

参考文献

VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/11190 A1, 2008 ;
Location in patent: Page/Page column 50 ;
WO 2008/011190 A1

616-05-72-溴己酸+

75-05-8乙腈

参考文献

Polivin, Yu. N.; Vinokurov, V. A.; Makarshin, S. V.; Karakhanov, R. A.; Silin, M. A.; Ageev, E. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 7.2 p. 1528 - 1530
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 7 p. 1682 - 1684

616-05-72-溴己酸+

127-06-0丙酮肟

5001-38-7

参考文献

Klemm,L.H.; Hsu Lee,D.
Journal of Medicinal Chemistry, 1966 , vol. 9, p. 435 - 436

616-05-72-溴己酸

5001-41-2

参考文献

Klemm,L.H.; Hsu Lee,D.
Journal of Medicinal Chemistry, 1966 , vol. 9, p. 435 - 436

616-05-72-溴己酸

5001-44-5丙酮 O-[1-(羟基甲基)戊基]肟

参考文献

Klemm,L.H.; Hsu Lee,D.
Journal of Medicinal Chemistry, 1966 , vol. 9, p. 435 - 436

616-05-72-溴己酸

628-05-71-硝基戊烷

参考文献

Henry
Recueil des Travaux Chimiques des Pays-Bas, 1905 , vol. 24, p. 332,337
Chem. Zentralbl., 1905 , vol. 76, # I p. 1697

616-05-72-溴己酸

6316-12-7

参考文献

Ackerman et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 6524

参考文献

Ioannou, Panayiotis V.
Phosphorus, Sulfur and Silicon and Related Elements, 2002 , vol. 177, # 1 p. 1 - 14

616-05-72-溴己酸+

950-59-42,6-二叔丁基-4-巯基苯酚

53602-61-2

参考文献

Wagner,E.R. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 1007 - 1013

616-05-72-溴己酸+

124-40-3二甲胺

5428-01-3

参考文献

Friedmann
B.Ph.P., 1908 , vol. 11, p. 200