(S)-(+)-2-辛醇合成路线 （共 200 条）
反应条件
Candida antarctica lipase B; (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 20 h;
参考文献
Martin-Matute, Belen; Edin, Michaela; Bogar, Krisztian; Kaynak, F. Betuel; Baeckvall, Jan-E.
Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8817 - 8825
反应条件
His-tagged Pseudomonas sp. metallo-β-lactamase-type alkylsulfatase Pisa1; water; tris(hydroxymethyl)methylamine hydrochloride T=30°C; pH=8.2; 6 h; Enzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Schober, Markus; Gadler, Petra; Knaus, Tanja; Kayer, Heidemarie; Birner-Gruenberger, Ruth; Guelly, Christian; MacHeroux, Peter; Wagner, Ulrike; Faber, Kurt
Organic Letters, 2011 , vol. 13, # 16 p. 4296 - 4299
反应条件
lipase-lipide in 2,2,4-trimethylpentane T=40°C; Product distributionRate constant;
参考文献
Tetrahedron Letters, , vol. 29, # 40 p. 5133 - 5134
反应条件
[(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one in toluene T=70°C; P=142.511 Torr; 40 h;
参考文献
Verzijl, Gerard K.M.; De Vries, Johannes G.; Broxterman, Quirinus B.
Tetrahedron Asymmetry, 2005 , vol. 16, # 9 p. 1603 - 1610
反应条件
tri-n-butyl-tin hydride in dichloromethane T=18°C; 0.416667 h; Inert atmospherePhotolysis; enantioselective reaction;
参考文献
Hartung, Jens; Kempter, Irina; Gottwald, Thomas; Schwarz, Michaela; Kneuer, Rainer
Tetrahedron Asymmetry, 2009 , vol. 20, # 18 p. 2097 - 2104
反应条件
Arthrobacter atrocyaneus in N,N-dimethyl-formamide T=32°C; 48 h; Microbiological reaction; enantioselective reaction;
参考文献
Silva, Camila R.; Souza, Juliana C.; Araujo, Lidiane S.; Kagohara, Edna; Garcia, Thais P.; Pelizzari, Vivian H.; Andrade, Leandro H.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 83, p. 23 - 28
反应条件
(1S,2R)-(-)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol 1.) hexane, rt, 20 min 2.) hexane, 0 deg C, 16 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 56, # 13 p. 4264 - 4268
反应条件
sodium hypophosphite; Raney Ni(W-2) in ethanol; water 0.5 h; Ambient temperature;
参考文献
Node, Manabu; Nishide, Kiyoharu; Shigeta, Yukihiro; Obata, Kenichi; Shiraki, Hiroaki; Kunishige, Hideaki
Tetrahedron, 1997 , vol. 53, # 38 p. 12883 - 12894
反应条件
immobilized Candida antarctica Lipase B; potassium carbonate; n-hexyl methyl ketone; chiral ruthenium-based in toluene T=70°C; P=150.012 Torr; 23 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 15 p. 2299 - 2305
反应条件
water; sodium hydroxide in methanol 6 h; RefluxInert atmosphere;
参考文献
Maywald, Matthias; Pfaltz, Andreas
Synthesis, 2009 , # 21 p. 3654 - 3660
