反应条件
1: tetrahydrofuran; diethyl ether / 2 h / 0 °C 2: tetrahydrofuran; diethyl ether / 1 h / 0 °C 3: CH2Cl2 / 12 h / 20 °C 5: 50 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH2Cl2 / 10 h / Ambient temperature 6: 1.) LDA / 1.) THF, hexane, -78 deg C, 8 h, 2.) THF, hexane, RT, 12 h 7: 93 percent / Pd(PPh3)2(OAc)2, CuI, diethylamine / dimethylformamide / 2 h / Ambient temperature 8: H2, quinoline / Lindlar's catalyst / 1.) EtOAc, hexane, RT, 1 h, 2.) isooctane, reflux, 2 h 9: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Figadere; Norman; Henry; Koeffler; Zhou; Okamura
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2452 - 2463
