2-氨基-5-溴噻唑-4-甲酸乙酯合成路线 （共 9 条）
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 572 - 576
反应条件
bromine; thiourea in concentrated hydrobromic acid
反应条件
copper(ll) bromide; isopentyl nitrite in acetonitrile T=0°C; 2 h;
参考文献
Okonya, John F; Al-Obeidi, Fahad
Tetrahedron Letters, 2002 , vol. 43, # 39 p. 7051 - 7053
反应条件
1: acetic acid With N-ethyl-N,N-diisopropylamine; 2-bromo-3,4-dimethyl-thiazolium bromide in dichloromethane T=25°C; 0.166667 h; 2: 2-amino-5-bromthiazol-4-carbonic acid ethyl ester in dichloromethane
参考文献
BAYER AG
Patent: EP1371651 A2, 2003 ;
Location in patent: Page 10 ;
反应条件
acetic acid; N-ethyl-N,N-diisopropylamine in hexane; dichloromethane; ethyl acetate
参考文献
Wischnat, Ralf; Rudolph, Joachim
Patent: US2004/19219 A1, 2004 ;
反应条件
(i) NaNO2, aq. H2SO4, (ii) aq. H3PO2, (iii) aq. HCl; Multistep reaction;
参考文献
Blank,B. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 572 - 576
反应条件
(i) NaNO2, aq. H2SO4, (ii) aq. H3PO2; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 572 - 576
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) aq. H3PO2
2: (i) NaH, DMSO, (ii) /BRN= 1210846/
3: (i) Hg(OAc)2, CF3CO2H, (ii) H2S
View Scheme
参考文献
Blank,B. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 572 - 576
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) aq. H3PO2
2: (i) NaH, DMSO, (ii) /BRN= 1210846/
View Scheme
参考文献
Blank,B. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 572 - 576
