4-甲基-N-苯基苯胺合成路线 （共 140 条）
反应条件
1: p-toluidine With n-butyllithium in hexane; chlorobenzene T=0 - 20°C; 0.5 h; 2: With zinc(II) chloride−TMEDA in hexane; chlorobenzene 1 h; 3: PhZnPh With iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane in hexane; chlorobenzene T=80°C; 15 h;
参考文献
Nakamura, Yuki; Ilies, Laurean; Nakamura, Eiichi
Organic Letters, 2011 , vol. 13, # 22 p. 5998 - 6001
反应条件
palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1-methyl-pyrrolidin-2-one T=150°C; 24 h; Inert atmosphereSealed vessel;
参考文献
Xie, Yanjun; Liu, Saiwen; Liu, Yong; Wen, Yuqing; Deng, Guo-Jun
Organic Letters, 2012 , vol. 14, # 7 p. 1692 - 1695
反应条件
1: p-toluidine With n-butyllithium; ZnCl2*TMEDA in tetrahydrofuran; hexane T=0 - 20°C; 0.5 h; Inert atmosphereSchlenk technique; 2: phenyl-magnesium bromide With N,N'-dimethyl-N,N'-propyleneurea; bis(acetylacetonate)nickel(II); 1,2-dichloro-2-methylpropane in tetrahydrofuran; hexane T=0 - 20°C; 3 h; Inert atmosphereSchlenk technique; Reagent/catalystSolvent;
参考文献
Ilies, Laurean; Matsubara, Tatsuaki; Nakamura, Eiichi
Organic Letters, 2012 , vol. 14, # 21 p. 5570 - 5573,4
反应条件
caesium carbonate; palladium diacetate in toluene T=100°C; 8 h;
参考文献
Chemical Communications, , # 43 p. 4516 - 4518
反应条件
palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1-methyl-pyrrolidin-2-one T=150°C; 24 h; Inert atmosphereSealed vessel;
参考文献
Xie, Yanjun; Liu, Saiwen; Liu, Yong; Wen, Yuqing; Deng, Guo-Jun
Organic Letters, 2012 , vol. 14, # 7 p. 1692 - 1695
反应条件
1: p-toluidine With n-butyllithium; ZnCl2*TMEDA in tetrahydrofuran; hexane T=0 - 20°C; 0.5 h; Inert atmosphereSchlenk technique; 2: phenyl-magnesium bromide With N,N'-dimethyl-N,N'-propyleneurea; bis(acetylacetonate)nickel(II); 1,2-dichloro-2-methylpropane in tetrahydrofuran; hexane T=0 - 20°C; 3 h; Inert atmosphereSchlenk technique; Reagent/catalystSolvent;
参考文献
Organic Letters, , vol. 14, # 21 p. 5570 - 5573,4
反应条件
1,10-phenanthroline; oxygen; palladium diacetate in toluene T=135°C; 37 h; Sealed tube;
参考文献
Girard, Simon A.; Knauber, Thomas; Zhou, Feng; Simon, Marc-Olivier; Li, Chao-Jun; Hu, Xiong; Deng, Guo-Jun
Organic Letters, 2012 , vol. 14, # 21 p. 5606 - 5609,4
反应条件
1: With caesium carbonate; chloroacetyl chloride in N,N-dimethyl-formamide T=20°C; Smiles rearrangement; 0.5 h; 2: in N,N-dimethyl-formamide T=150°C; Smiles rearrangement; Microwave irradiation;
参考文献
Tian, Xiao; Wu, Ren-Min; Liu, Gang; Li, Zhu-Bo; Wei, He-Lin; Yang, Hao; Shin, Dong-Soo; Wang, Li-Ying; Zuo, Hua
Arkivoc, 2011 , vol. 2011, # 10 p. 118 - 126
反应条件
copper(l) iodide; potassium carbonate man verseift das erhaltene Essigsaeure-<phenyl-p-toluidid> durch Kochen mit Salzsaeure und Alkohol;
参考文献
Chemische Berichte, , vol. 40, p. 4543
反应条件
2-(di-tert-butylphosphino)-2'-isopropoxy-1,1'-binaphthyl; potassium phosphate; palladium diacetate; 3,4,5-trimethoxyphenylboronic acid in butan-1-ol T=110°C; 15 h; Inert atmosphere;
参考文献
Xie, Xiaomin; Ni, Gang; Ma, Fangfang; Ding, Lina; Xu, Sheng; Zhang, Zhaoguo
Synlett, 2011 , # 7 p. 955 - 958
