hydrogen bromide T=120°C; 2 h;

1: dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature 2: H2, conc. HCl / PtO2 / methanol / 2585.7 Torr 3: Et3N / toluene / 0.5 h / Ambient temperature 4: LiAlH4 / tetrahydrofuran / 3 h / Heating 5: 85 percent / 48percent aq. HBr / 2 h / 120 °C View Scheme

1: dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature 2: H2, conc. HCl / PtO2 / methanol / 2585.7 Torr 3: Et3N / toluene / 0.5 h / Ambient temperature 4: LiAlH4 / tetrahydrofuran / 3 h / Heating 5: 85 percent / 48percent aq. HBr / 2 h / 120 °C View Scheme

1: H2, conc. HCl / PtO2 / methanol / 2585.7 Torr 2: Et3N / toluene / 0.5 h / Ambient temperature 3: LiAlH4 / tetrahydrofuran / 3 h / Heating 4: 85 percent / 48percent aq. HBr / 2 h / 120 °C View Scheme

1: Et3N / toluene / 0.5 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 3 h / Heating 3: 85 percent / 48percent aq. HBr / 2 h / 120 °C View Scheme

1: LiAlH4 / tetrahydrofuran / 3 h / Heating 2: 85 percent / 48percent aq. HBr / 2 h / 120 °C View Scheme

phosphate buffer; ethylenediaminetetraacetic acid; NADPH; magnesium chloride; ascorbic acid powder; rat liver microsome in water T=37°C; Rate constantEquilibrium constant;