1,3,5-三甲氧基苯合成路线 （共 273 条）
反应条件
1: phloroglucinol trimethyl ether With boron tribromide in dichloromethane
T=0 - 20°C; Inert atmosphere;
2: acetic acid in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Balaydin, Halis T.
Journal of Chemical Research, 2012 , vol. 36, # 4 p. 238 - 240
反应条件
in acetonitrile
Photolysis;
参考文献
Thomas, Selina I.; Falvey, Daniel E.
Journal of Organic Chemistry, 2007 , vol. 72, # 13 p. 4626 - 4634
反应条件
gold(III) chloride; silver trifluoromethanesulfonate in 1,2-dichloro-ethane
T=80°C;
参考文献
Li, Zigang; Shi, Zhangjie; He, Chuan
Journal of Organometallic Chemistry, 2005 , vol. 690, # 23 p. 5049 - 5054
反应条件
sulfuric acid in diethyl ether
参考文献
Donnelly,J.A.; Maloney,D.E.
Tetrahedron, 1979 , vol. 35, p. 2883 - 2888
反应条件
1.1: dichloromethane / 0.17 h / 0 °C
1.2: 2 h
2.1: AlCl3, aluminium chloride / dichloromethane / 24 h / 0 °C / |Reflux
3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
3.2: 0.5 h / |Reflux
4.1: sodium hydride / tetrahydrofuran / 1.67 h / 0 °C / |Reflux
5.1: potassium carbonate / acetone / 0.5 h
5.2: 24 h / |Reflux
6.1: sulfuric acid / acetic acid / 0.5 h / 20 °C
7.1: methanol; sodium tetrahydroborate / 0.5 h
8.1: sulfuric acid / 3 h / |Reflux
9.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere
10.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
10.2: 2 h / 0 - 20 °C
11.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere
View Scheme
参考文献
Zhang, Wen-Jing; Wu, Jing-Fang; Zhou, Peng-Fei; Wang, Yang; Hou, Ai-Jun
Tetrahedron, 2013 , vol. 69, # 29 p. 5850 - 5858
反应条件
1: With boron trifluoride diethyl etherate
T=100°C; 4 h;
2: in ethanol; water
2 h; Reflux;
参考文献
Liu, Man; Zhang, Ji; Yang, Jian; Yang, Bo; Cui, Wei
Journal of Chemical Research, 2014 , vol. 38, # 3 p. 134 - 136
反应条件
1.1: boron trifluoride diethyl etherate / ethyl acetate / 2.5 h / 20 °C
2.1: boron trichloride / dichloromethane / 2 h / 0 °C
2.2: 1 h
3.1: potassium hydroxide / methanol / 80 h / 20 °C
3.2: pH 5 - 6
View Scheme
参考文献
Liu, Man; Zhang, Ji; Yang, Jian; Yang, Bo; Cui, Wei
Journal of Chemical Research, 2014 , vol. 38, # 3 p. 134 - 136
反应条件
tin(IV) chloride in dichloromethane
T=-15 - -10°C; 2 h;
参考文献
Tanaka, Tomohiro; Kumamoto, Takuya; Ishikawa, Tsutomu
Tetrahedron Asymmetry, 2000 , vol. 11, # 23 p. 4633 - 4637
反应条件
trifluorormethanesulfonic acid
1.) room temperature, 3 h, 2.) 13 d; Yield given. Multistep reaction;
参考文献
Booth, Brian L.; Noori, Ghazi F.M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2894 - 2900
反应条件
copper(l) iodide; oxygen in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Zhang, Shouhui; Qian, Pengcheng; Zhang, Manli; Hu, Maolin; Cheng, Jiang
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6732 - 6735
