3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: 81 percent / K2CO3, KI / dimethylformamide / 21 h / 65 °C 2: 92 percent / sulfamic acid, aq. AcOH, aq. NaClO2 / 1 h / Ambient temperature 3: 98 percent / SOCl2 / toluene; dimethylformamide / 5 h / Heating 4: Et3N / CH2Cl2 / 5 h / 60 °C View Scheme
参考文献
Ashton, Michael J.; Cook, David C.; Fenton, Garry; Karlsson, Jan-Anders; Palfreyman, Malcolm N.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1696 - 1703
反应条件
potassium carbonate in N,N-dimethyl-formamide T=40 - 50°C; 5 h;
参考文献
Nakazato, Atsuro; Ohta, Kohmei; Sekiguchi, Yoshinori; Okuyama, Shigeru; Chaki, Shigeyuki; Kawashima, Yutaka; Hatayama, Katsuo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 1076 - 1087
反应条件
triphenylphosphine in tetrahydrofuran; diethyl ether
参考文献
Nikken Chemicals Co., Ltd.
Patent: US6235739 B1, 2001 ;
反应条件
in tetrahydrofuran; ethyl acetate
参考文献
Nikken Chemicals Co., Ltd.
Patent: US6265402 B1, 2001 ;
反应条件
acetic acid in ethanol Reflux;
参考文献
Makam, Parameshwar; Kankanala, Ramakrishna; Prakash, Amresh; Kannan, Tharanikkarasu
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 564 - 576
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 20 °C 2: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethanol; water / 760.05 Torr View Scheme
参考文献
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
Patent: EP2511283 A1, 2012 ;
反应条件
3: CsF 4: acid treatment 5: OH(1-) 9: 2.) p-toluenesulfonic acid / 1.) xylene, 2.) reflux View Scheme
参考文献
Ishii; Ishikawa; Takeda; Ueki; Suzuki; Harayama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 6 p. 1775 - 1777
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C;
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 787 - 797
反应条件
1: magnesium monoperoxyphthalate hexahydrate / methanol; H2O / 17 h / Ambient temperature 2: methanol / 18 h / Ambient temperature View Scheme
参考文献
Jerezano, Alberto; Jimenez, Fabiola; Del Carmen Cruz, Maria; Montiel, Luisa E.; Delgado, Francisco; Tamariz, Joaquin
Helvetica Chimica Acta, 2011 , vol. 94, # 2 p. 185 - 198
反应条件
1: 91 percent / pyridine / CH2Cl2 / 0.25 h / 0 °C 2: 67 percent / Et3N / PdCl2(dppf) / dioxane / Heating 3: 59 percent / aq. CuBr2 / methanol / Heating View Scheme
参考文献
Thompson, Alicia L. S.; Kabalka, George W.; Akula, Murthy R.; Huffman, John W.
Synthesis, 2005 , # 4 art. no. M05304SS, p. 547 - 550
