3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1.1: 92 percent / K2CO3 / acetone 2.1: K2CO3 / acetone 3.1: potassium tert-butoxide / tetrahydrofuran / 0.17 h 3.2: 78 percent / tetrahydrofuran 4.1: 93 percent / Grubbs catalyst / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Huang, Keng-Shiang; Wang, Eng-Chi
Journal of the Chinese Chemical Society, 2004 , vol. 51, # 2 p. 383 - 391
反应条件
1: formic acid; hydroxylamine hydrochloride; sodium formate / 3 h / 125 °C 2: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 18 h / 0 °C / Reflux View Scheme
参考文献
Kumar, Dalip; Patel, Gautam; Vijayakrishnan, Lalitha; Dastidar, Sunanda G.; Ray, Abhijit
Chemical Biology and Drug Design, 2012 , vol. 79, # 5 p. 810 - 818
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=90°C;
参考文献
Xu, Li Bao; Sun, Wei; Liu, Hong Ying; Wang, Li Li; Xiao, Jun Hai; Yang, Xiao Hong; Li, Song
Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1318 - 1321
反应条件
1: 81 percent / K2CO3, KI / dimethylformamide / 21 h / 65 °C 2: 92 percent / sulfamic acid, aq. AcOH, aq. NaClO2 / 1 h / Ambient temperature View Scheme
参考文献
Cook, David C.; Jones, Ronald H.; Kabir, Humayun; Lythgoe, David J.; McFarlane, Ian M.; Pemberton, Clive; Thatcher, Alan A.; Thompson, David M.; Walton, John B.
Organic Process Research and Development, 1998 , vol. 2, # 3 p. 157 - 168
参考文献
SmithKline Beecham Corporation
Patent: US5449686 A1, 1995 ;
反应条件
triphenylphosphine in tetrahydrofuran; hexane
参考文献
Nikken Chemicals Co., LTD
Patent: US6251897 B1, 2001 ;
反应条件
1: 67 percent / diisopropylethylamine / dimethylformamide / 2 h / 20 °C 2: 62 percent / triphenylphosphine / CH2Cl2 / 0.33 h / 0 °C 3: 88 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C 4: 58 percent / tributyltin hydride; pyridine / tetrakis(triphenylphosphine)palladium(0) / benzene 5: 71 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Bedford, Simon B.; Quarterman, Charmaine P.; Rathbone, Daniel L.; Slack, John A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 2 p. 157 - 160
反应条件
potassium hydrogencarbonate in dichloromethane; water T=20°C; Wittig coupling; 48 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 9 p. 2780 - 2784
反应条件
potassium carbonate in ethanol Wittig reaction; 8 h; RefluxInert atmosphere; optical yield given as percent de;
参考文献
Guo, Xiaotao; Zhang, Dan; Yu, Zhifang; Liu, Tianzhen; Li, Dachang; Li, Chunbao
Journal of Chemical Research, 2011 , vol. 35, # 4 p. 229 - 230
反应条件
1: acetic anhydride; triethylamine / 6 h / 110 °C 2: quinoline; copper / 3 h / 200 °C / Inert atmosphere View Scheme
参考文献
Xiao, Chun-Fen; Zou, Yong; Du, Jian-Li; Sun, Hong-Yi; Liu, Xian-Ke
Synthetic Communications, 2012 , vol. 42, # 9 p. 1243 - 1258
