3-羟基-4-甲氧基苯甲醛合成路线 （共 405 条）
反应条件
1: 48 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature
2: 100 percent / H2 / Pd/C
3: 67 percent / polyphosphoric acid / CHCl3 / 40 °C
4: 100 percent / K2CO3 / dimethylformamide / Heating
5: 42 percent / NH3(liq.), t-C4H9OK, air / Irradiation
6: 96 percent / 30percent Pd/C / 4 h / 250 °C
7: 90 percent / 48percent HBr / acetic acid / 3 h / 100 °C
View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
1: potassium carbonate / ethanol / 20 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C
3: sodium hydroxide / methanol; water / 0.08 h / 20 °C
4: N-bromosuccinmide / tetrahydrofuran / 0.58 h / -78 °C / Inert atmosphere
View Scheme
参考文献
Nemecek, Gregor; Cudaj, Judith; Podlech, Joachim
European Journal of Organic Chemistry, 2012 , # 20 p. 3863 - 3870
反应条件
1: H2, AcOH / 10percent Pd/C / ethyl acetate / 760 Torr
2: 4.13 g / Fremy's salt, NaH2PO4 / H2O; acetone / 0.5 h
View Scheme
参考文献
Burke, John M.; Stevenson, Robert
Journal of Chemical Research, Miniprint, 1985 , # 2 p. 451 - 466
反应条件
1: methanol; aqueous formaldehyde; aqueous KOH
2: K2CO3; acetone
3: 230 °C
4: K2CO3
5: KMnO4; aqueous NaOH
View Scheme
参考文献
Schwarz; Capek
Monatshefte fuer Chemie, 1953 , vol. 84, p. 595,604
反应条件
potassium permanganate; triphenylphosphine in tetrahydrofuran; water; ethyl acetate; acetone; Petroleum ether
参考文献
The Trustees of Columbia University in the City of New York; Cold Spring Harbor Laboratory
Patent: US6503759 B1, 2003 ;
