3-(2-溴乙酰基)吡啶合成路线 （共 15 条）
反应条件
potassium carbonate in methanol T=25 - 30°C; 4 h;
参考文献
AB SCIENCE
Patent: WO2008/98949 A2, 2008 ;
Location in patent: Page/Page column 18; 19-20 ;
WO 2008/098949 A2
反应条件
diethyl malonate Erhitzen der Reaktionsloesung mit wss. HCl;
参考文献
Wingfield
Journal of Organic Chemistry, 1959 , vol. 24, p. 872
反应条件
T=100°C; Bredereck Imidazole Synthesis; 0.25 h;
参考文献
Liu, Cong; Nie, Yijiao; Yao, Guowei; Dai, Rongji; Deng, Yulin
Journal of Chemical Research, 2014 , vol. 38, # 4 p. 208 - 210
反应条件
selenium(IV) oxide 16 h; Reflux;
参考文献
LIGAND PHARMACEUTICALS INC.; COLE, Andrew; MCGUINNESS, Brian, F.; SHAO, Yuefei; DONG, Guizhen; HENDERSON, Ian
Patent: WO2010/8775 A1, 2010 ;
Location in patent: Page/Page column 31-32 ;
WO 2010/008775 A1
反应条件
hydrogen bromide 1 h; Heating; Yields of byproduct given;
参考文献
Novikova, A. P.; Perova, N. M.; Egorova, L. G.; Bragina, E. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 6 p. 666 - 668
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , vol. 27, # 6 p. 843 - 846
反应条件
sodium borohydride in methanol
参考文献
Denny, William Alexander; Hutchings, Richard H; Johnson, Douglas S; Kaltenbronn, James Stanely; Lee, Ho Huat; Leonard, Daniele Marie; Milbank, Jared Bruce John; Repine, Joseph Thomas; Rewcastle, Gordon William; White, Andrew David
Patent: US2004/44057 A1, 2004 ;
反应条件
hydrogen bromide; bromine in acetic acid
T=70°C; 3 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; DUNCIA, John V.; HYNES, John; NAIR, Satheesh K.; PITTS, William J.; KUMAR, Sreekantha R.; GARDNER, Daniel S.; MURUGESAN, Natesan; PAIDI, Venkatram Reddy; SANTELLA, Joseph B.; SISTLA, Ramesh; WU, Hong
Patent: WO2014/74675 A1, 2014 ;
Location in patent: Paragraph 00221 ;
反应条件
hydrogen bromide; bromine
参考文献
Denny, William Alexander; Hutchings, Richard H; Johnson, Douglas S; Kaltenbronn, James Stanely; Lee, Ho Huat; Leonard, Daniele Marie; Milbank, Jared Bruce John; Repine, Joseph Thomas; Rewcastle, Gordon William; White, Andrew David
Patent: US2004/44057 A1, 2004 ;
反应条件
diethyl ether; water; hydrogen bromide; benzene
参考文献
Burger et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 1327
反应条件
water; hydrogen bromide; bromine
Anschliessenden Erwaermen;
参考文献
Wunderlich
Journal fuer Praktische Chemie (Leipzig), 1955 , vol. <4> 2, p. 302,306
