反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h; Inert atmosphere;
2: With zinc trimethylacetate in tetrahydrofuran; hexane
T=-78 - 25°C; Inert atmosphere;
3: 1-methoxy-4-chlorobenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran
T=50°C; Negishi Coupling; 12 h; Inert atmosphereSchlenk technique; SolventReagent/catalyst;
参考文献
Colombe, James R.; Bernhardt, Sebastian; Stathakis, Christos; Buchwald, Stephen L.; Knochel, Paul
Organic Letters, 2013 , vol. 15, # 22 p. 5754 - 5757
