2,4-二羟基-6-甲基嘧啶合成路线 （共 187 条）
反应条件
1: 83 percent / phosphorus oxychloride / 3 h / Heating
2: 1.) sodium; / 1.) toluene, 0 deg C, 2 h; 2.) reflux, 16 h
3: 94 percent / bromine / CH2Cl2 / 0 °C
View Scheme
参考文献
Hung; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 741 - 744
反应条件
1: 64 percent / POCl3 / 3 h / Heating
2: 50 percent / lithium perchlorate / diethyl ether / 24 h
View Scheme
参考文献
McCluskey, Adam; Keller, Paul A.; Morgan, Jody; Garner, James
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3353 - 3361
反应条件
in water
T=20°C; pH 8.6; Rate constantEquilibrium constant;
参考文献
Steenken; Telo; Novais; Candeias
Journal of the American Chemical Society, 1992 , vol. 114, # 12 p. 4701 - 4709
参考文献
Behrend; Gruenewald
Justus Liebigs Annalen der Chemie, 1902 , vol. 323, p. 196
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Behrend; Osten
Justus Liebigs Annalen der Chemie, 1905 , vol. 343, p. 138
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Behrend; Dietrich
Justus Liebigs Annalen der Chemie, 1899 , vol. 309, p. 278
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Behrend
Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 17
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 249
参考文献
Behrend; Gruenewald
Justus Liebigs Annalen der Chemie, 1902 , vol. 323, p. 196
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Behrend; Osten
Justus Liebigs Annalen der Chemie, 1905 , vol. 343, p. 138
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Behrend; Dietrich
Justus Liebigs Annalen der Chemie, 1899 , vol. 309, p. 278
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Behrend
Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 17
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 249
反应条件
sulfuric acid
durch elektrolytische Reduktion;
参考文献
Tafel; Weinschenk
Chemische Berichte, 1900 , vol. 33, p. 3370
反应条件
1: 73 percent / 5percent aq NaOH / H2O / 16 h / Ambient temperature
2: 63 percent / K2S2O8, AgNO3 / H2O / 1.) 90-100 deg C; 2.) room temp. 16 h
3: 40 percent / dimethylformamide / 96 h / Ambient temperature
4: 90 percent / NaOH / methanol; dioxane; H2O / 16 h / 40 °C
5: 1.) Triethylamine; 2.) Hydroxybenztriazole, DCC / DMF, room temp., 16 h
6: 63 percent / LiBH4 / 1,2-dimethoxy-ethane / 1.) -78 deg C; 2.) room temp., 2 h
View Scheme
参考文献
Ottenheijm, Harry C.J.; Liskamp, Rob M.J.; Nispen, Simon P.J.M. van; Boots, Hans A.; Tijhuis, Marian W.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3273 - 3283
反应条件
dihydrogen peroxide; bromine; acetic acid
T=20°C; 1 h; Reagent/catalystConcentrationTime;
参考文献
Kasradze; Ignatyeva; Khusnutdinov; Suponitskii, K. Yu.; Antipin, M. Yu.; Yunusov
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 7 p. 1018 - 1027
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 7 p. 1095 - 1106,12
反应条件
dihydrogen peroxide; bromine in water
T=20°C; 1 h;
参考文献
Kasradze; Ignatyeva; Khusnutdinov; Suponitskii, K. Yu.; Antipin, M. Yu.; Yunusov
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 7 p. 1018 - 1027
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 7 p. 1095 - 1106,12
反应条件
tetrabutylammomium bromide; potassium carbonate in N,N-dimethyl-formamide
T=90°C; 4 h;
参考文献
Krivonogov; Tolstikov; Murinov; Spirikhin; Fatykhov; Abdrakhmanov
Russian Journal of Applied Chemistry, 1997 , vol. 70, # 2 p. 301 - 306
