2,4-二羟基-6-甲基嘧啶合成路线 （共 187 条）
反应条件
in sodium hydroxide; acetone
参考文献
Tateoka; Kimura; Watanabe; Yamamoto; Ho
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 12 p. 4928 - 4934
反应条件
dibenzoyl peroxide
T=80°C; 7 h;
参考文献
Itahara, Toshio; Ide, Naoko
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 4 p. 1225 - 1226
反应条件
1: 80 percent / Br2 / H2O / 0.5 h
2: 85 percent / POCl3 / dimethylformamide / 3 h / Heating
3: 90 percent / NH3 / ethanol / 12 h / 20 °C
View Scheme
参考文献
Yanai
Yakugaku Zasshi, 1942 , vol. 62, p. 315,333; dtsch. Ref. S. 95, 106
Chem.Abstr., 1951 , p. 5150
反应条件
1.1: aq. NaOH / 70 °C
1.2: 70 percent / 1 h / 80 °C
2.1: 86 percent / H2SO4; HNO3 / 1 h / 0 °C
View Scheme
参考文献
Azas, Nadine; Rathelot, Pascal; Djekou, Serge; Delmas, Florence; Gellis; Di Giorgio, Carole; Vanelle, Patrice; Timon-David, Pierre
Farmaco, 2003 , vol. 58, # 12 p. 1263 - 1270
反应条件
sodium ethanolate; N,N-dimethyl-aniline; trichlorophosphate
1.) 100 deg C, 3 h, 2.) 0 deg C, 2 h; reflux, 3 h; Yield given. Multistep reaction;
参考文献
Wada; Yasuda; Kanatomo
Synthesis, 1988 , # 10 p. 771 - 775
反应条件
1: 83 percent / conc. H2SO4, fuming HNO3 (d 1.5) / 0 °C
2: 91 percent / fuming HNO3 (d 1.5) / 4 h / 100 °C
3: 97 percent / conc. H2SO4 / 9 h / Heating
View Scheme
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
反应条件
diphosphorus pentasulfide; sodium hydrogencarbonate in diethylene glycol dimethyl ether
T=110°C; 1 h;
参考文献
Lapucha, Andrzej R.
Synthesis, 1987 , # 3 p. 256 - 258
