反应条件
1: 1.) LDA / 1.) - 78 deg C, 10 min 2.) -78 deg C, 1 h and warming to 25 deg C, 1 h.
2: 89 percent / tetrahydrofuran / 25 °C
3: 90 percent / NaBH4 / ethanol / 1 h / -30 °C
5: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
6: 1.) CuCN / 1.) -78 deg C, 1 h 2.) - 78 deg C, 1 h and -45 deg C, 14 h
7: 87 percent / MeOH, p-TsOH / 12 h / 25 °C
8: 83 percent / hydrogen / 5percent Pd-CaCO3 / benzene / 25 °C / 760 Torr / cat. 10percent by weight
9: hydrogen / ethyl acetate / 25 °C / 760 Torr / cat. 50percent by weight
View Scheme
参考文献
Corey; Pyne; Schafer
Tetrahedron Letters, 1983 , vol. 24, # 32 p. 3291 - 3294
