1: 3-bromo-pyridine With n-butyllithium in tetrahydrofuran; diethyl ether; hexane
T=-90°C; 0.25 h;
2: 2-Pyridinecarboxylic acid methyl ester in various solvents
T=-110 - 20°C; 4 h;
参考文献
Popova, I. S.; Formanovsky, A. A.; Mikhura, I. V.
Russian Chemical Bulletin, 2002 , vol. 51, # 3 p. 540 - 543
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 2002 , # 3 p. 501 - 504
1: 1-bromo-octane With magnesium in diethyl ether
Heating;
2: 3-bromo-pyridine With Cl2Ni(1,2-bis(diphenylphosphino)ethane) in diethyl ether
Heating; Further stages.;
参考文献
Getmanenko, Yulia A.; Twieg, Robert J.
Journal of Organic Chemistry, 2008 , vol. 73, # 3 p. 830 - 839
n-C4H9Li in diethyl ether; hexane
(Ar); a soln. of n-BuLi in hexane added dropwise at -78°C to an ether soln. of 3-bromopyridine; after 3 h, Me3SnCl in ether added over a period of 10 min at -78°C, stirred for 30 min at -78°C, warmed slowly to room temp.; washed (H2O), the org. phase dried over MgSO4, solvent-removed, chromd. (silica gel, EtOAc/hexane); obtained as an oil;
参考文献
Janka, Mesfin; Anderson, Gordon K.; Rath, Nigam P.
Inorganica Chimica Acta, 2004 , vol. 357, # 8 p. 2339 - 2344
