1: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=62 - 75°C; 5 h; Inert atmosphere;
2: With hydrogenchloride in tert-butyl methyl ether; water; toluene
Cooling with ice-water;
3: With sodium hydroxide in tert-butyl methyl ether; water
pH=13; Cooling with ice-water;
参考文献
TARGACEPT, INC.
Patent: WO2009/91561 A1, 2009 ;
Location in patent: Page/Page column 29 ;
