1: 41 percent / copper / aq. KOH / 1.) 0 degC, 1 h, 2.) R.T. 3.5 h 2: 82 percent / 1.) triphenylphosphine, bromine, triethylamine / benzene / 1.) 0 degC, 2.) R.T. 4 h 3: 93 percent / diethyl ether / 1.) -78 degC, 10 min., 2.) 0 degC, 1 h View Scheme

1: 1) NaH / 1) allylalcohol, mineral oil, 90 deg C, 3 h; 2) 100 deg C, 3-4 h 2: 55 percent Chromat. / Pd(OAc)2, bis(diphenylphosphino)ethane / acetonitrile / Heating 3: NaOMe / methanol / 10 h / 0 °C 4: 90 percent / adipic acid / 6 h / 190 °C View Scheme

1: 1) NaH / 1) allylalcohol, mineral oil, 90 deg C, 3 h; 2) 100 deg C, 3-4 h 2: 55 percent Chromat. / Pd(OAc)2, bis(diphenylphosphino)ethane / acetonitrile / Heating 3: NaOMe / methanol / 10 h / 0 °C View Scheme

1: 1) NaH / 1) allylalcohol, mineral oil, 90 deg C, 3 h; 2) 100 deg C, 3-4 h 2: 55 percent Chromat. / Pd(OAc)2, bis(diphenylphosphino)ethane / acetonitrile / Heating View Scheme

Multi-step reaction with 2 steps 1: 1) NaH / 1) allylalcohol, mineral oil, 90 deg C, 3 h; 2) 100 deg C, 3-4 h2: 27 percent Chromat. / Pd(OAc)2, bis(diphenylphosphino)ethane / acetonitrile / Heating