2'-氯-2,2-二甲基丙苯胺合成路线 （共 7 条）
反应条件
1: 72.1 percent / TMEDA, n-BuLi / various solvent(s); hexane / 1.) -12 to -20 deg C, 50min, 2.) -20 deg C, 2 h 2: conc. aq. HBr / 4.5 h / Heating View Scheme
参考文献
Mulhern, Thomas A.; Davis, Mark; Krikke, James J.; Thomas, James A.
Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5537 - 5540
反应条件
triethylamine in tetrahydrofuran
T=0°C; 3 h; Inert atmosphere;
参考文献
Sadig, Jessie E. R.; Foster, Radleigh; Willis, Michael C.; Wakenhut, Florian
Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9473 - 9486,14
反应条件
palladium diacetate; copper diacetate; copper dichloride in dichloromethane
T=90°C; 48 h;
参考文献
Wan, Xiaobing; Ma, Zhongxun; Li, Bijie; Zhang, Keya; Cao, Shaokui; Zhang, Shiwei; Shi, Zhangjie
Journal of the American Chemical Society, 2006 , vol. 128, # 23 p. 7416 - 7417
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: N-chloro-succinimide; palladium diacetate; toluene-4-sulfonic acid / toluene / 4 h / 20 °C
View Scheme
参考文献
Bedford, Robin B.; Haddow, Mairi F.; Mitchell, Charlotte J.; Webster, Ruth L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 24 p. 5524 - 5527
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: N-chloro-succinimide; palladium diacetate; toluene-4-sulfonic acid / toluene / 4 h / 20 °C
View Scheme
参考文献
Bedford, Robin B.; Haddow, Mairi F.; Mitchell, Charlotte J.; Webster, Ruth L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 24 p. 5524 - 5527
参考文献
Gowda, B. Thimme; Jyothi; Jayalakshmi; Damodara
Journal of the Indian Chemical Society, 2005 , vol. 82, # 6 p. 564 - 568
反应条件
palladium diacetate; caesium carbonate; tris-(o-tolyl)phosphine; 2,2,2-trimethylacetic acid in 1-methyl-pyrrolidin-2-one
T=140°C; 48 h; Schlenk technique;
参考文献
Yan, Jia-Xuan; Li, Hu; Liu, Xiang-Wei; Shi, Jiang-Ling; Wang, Xin; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4945 - 4949
