2-氨基-5-甲氧基苯硫酚合成路线 （共 29 条）
反应条件
phenylmethylsulfonylbenzene; oxygen; potassium iodide in chlorobenzene
T=140°C; 24 h;
参考文献
Liao, Yunfeng; Jiang, Pengcheng; Chen, Shanping; Xiao, Fuhong; Deng, Guo-Jun
RSC Advances, 2013 , vol. 3, # 40 p. 18605 - 18608
反应条件
1.1: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 2.67 h / 0 °C / |Reflux
2.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C
3.1: potassium carbonate / acetonitrile / 0.5 h / |Reflux
3.2: |Reflux
View Scheme
参考文献
Cao, Xu; Wang, Shi-Ben; Deng, Xian-Qing; Liu, Da-Chuan; Quan, Zhe-Shan
Medicinal Chemistry Research, 2014 , vol. 23, # 4 p. 1829 - 1838
反应条件
hydrazine hydrate; N,N-dimethyl-formamide
0.00833333 h; Neat (no solvent)Microwave irradiation;
参考文献
Kalwania; Chomal; Choudhary, Savita
Asian Journal of Chemistry, 2011 , vol. 23, # 11 p. 5133 - 5136
反应条件
1: 77 percent / aq. K2CO3 / tetrahydrofuran
2: 76 percent / BBr3*Me2S / toluene / Heating
View Scheme
参考文献
Cao, Xu; Wang, Shi-Ben; Deng, Xian-Qing; Liu, Da-Chuan; Quan, Zhe-Shan
Medicinal Chemistry Research, 2014 , vol. 23, # 4 p. 1829 - 1838
参考文献
Tasler, Stefan; Mueller, Oliver; Wieber, Tanja; Herz, Thomas; Pegoraro, Stefano; Saeb, Wael; Lang, Martin; Krauss, Rolf; Totzke, Frank; Zirrgiebel, Ute; Ehlert, Jan E.; Kubbutat, Michael H.G.; Schaechtele, Christoph
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6728 - 6737
反应条件
1: N,N-dimethyl-formamide / 18 h / 140 °C
2: tin(ll) chloride; ethanol / 3 h / |Reflux
View Scheme
参考文献
Pan, Jinhe; Mason, Neale S.; Debnath, Manik L.; Mathis, Chester A.; Klunk, William E.; Lin, Kuo-Shyan
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1720 - 1726
反应条件
1: 65 percent / sodium acetate / ethanol / 4 h / Heating
2: 65 percent / H2O / 4 h / Heating
View Scheme
参考文献
Gupta, Kalpana; Gupta, Rajni; Gupta; Kumar
Heterocyclic Communications, 2002 , vol. 8, # 3 p. 265 - 270
反应条件
1: 21 percent / polyphosphoric acid / 1.5 h / 170 °C
2: 75 percent / BBr3 / CH2Cl2 / 16 h / 20 °C
View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
参考文献
UNIVERSITY OF PITTSBURGH
Patent: WO2006/14382 A1, 2006 ;
Location in patent: Page/Page column 47 ;
