反应条件
1: 38 percent / p-toluenesulfonic acid / CH2Cl2 / 0 °C 2: 93 percent / pyridine / 0 °C 3: 1.) sodium iodide, 2.) acetic acid / 1.) DMF, 100 deg C, 2.) THF, H2O, room temperature 4: 94 percent / triethylamine / diethyl ether / 5 h / 40 °C 5: 1.) sodium hydride / 2.) tetrakis(triphenylphosphine)palladium(0) / 1.) THF, 45 deg C, 10 min; room temperature,30 min, 2.) reflux, 4 h 6: 82.5 percent / hexamethylphosphoric acid triamide / 11 h / 90 °C 7: 89 percent / disodium hydrogen phosphate, 6percent sodium amalgam / ethanol; tetrahydrofuran / 2.5 h / -20 °C 8: 99 percent / hydrogen / 5percent palladium on barium carbonate / 3 h / 1520 Torr / Ambient temperature View Scheme
参考文献
Trost,B.M.; Verhoeven,T.R.
Journal of the American Chemical Society, 1980 , vol. 102, p. 4743
