3-(2-氯乙基)-6,7,8,9-四氢-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮合成路线 （共 8 条）
反应条件
hydrogenchloride; hydrogen; palladium in water T=20°C; P=1810.07 Torr; 8 h;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2004/35573 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
1: toluene-4-sulfonic acid / toluene / Reflux 2: trichlorophosphate / 1 h / Reflux 3: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 8, # 10 p. 988 - 995
反应条件
1: toluene-4-sulfonic acid / toluene / Reflux 2: trichlorophosphate / 1 h / Reflux 3: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 8, # 10 p. 988 - 995
反应条件
1: trichlorophosphate / 1 h / Reflux 2: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 8, # 10 p. 988 - 995
反应条件
sodium carbonate in water; N,N-dimethyl-formamide
参考文献
JANSSEN PHARMACEUTICA NV; ORTHO-CLINICAL DIAGNOSTICS, INC; HASPESLAGH, Pieter Rik; VLIEGEN, Maarten; HRYHORENKO, Eric; DECORY, Thomas R.; SANKARAN, Banumathi
Patent: WO2014/31601 A1, 2014 ;
Location in patent: Page/Page column 51; 52 ;
反应条件
sodium carbonate in methanol T=73 - 75°C; 4 - 4.5 h; Product distribution / selectivity;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2006/5974 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium hydroxide in water T=120 - 130°C; 1.5 h;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2004/35573 A1, 2004 ;
Location in patent: Page 9-11 ;
反应条件
sodium carbonate in water T=110 - 120°C; 0.666667 h; Product distribution / selectivity;
参考文献
Zhang, Guiling; Zhu, Yidong; Fan, Chuanwen; Zhang, Minghui; Wang, Jingyi
Patent: US2010/130740 A1, 2010 ;
Location in patent: Page/Page column 4 ;
