(1S)-反-1,2-环戊二醇合成路线 （共 17 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=4560 Torr; 5 h;
参考文献
Cunningham, Allan F.; Kuendig, E. Peter
Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1823 - 1825
反应条件
sodium hydroxide in water
参考文献
Eastman Kodak Company
Patent: US5312950 A1, 1994 ;
反应条件
Boc-L-(π-Me)-His-(A)Gly-L-Cha-L-Phe-OMe in toluene
T=-20°C; 9 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Mueller, Christian E.; Wanka, Lukas; Jewell, Kevin; Schreiner, Peter R.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 33 p. 6180 - 6183
反应条件
N-ethyl-N,N-diisopropylamine; (9S)-6'-methoxycinchonan-9-yl diphenylphosphinite in various solvent(s)
T=-78°C; 1 h; Title compound not separated from byproducts;
参考文献
Mizuta, Shinya; Ohtsubo, Yutaka; Tsuzuki, Takeo; Fujimoto, Tetsuya; Yamamoto, Iwao
Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8227 - 8229
反应条件
N-ethyl-N,N-diisopropylamine; (9S)-6'-methoxycinchonan-9-yl diphenylphosphinite in various solvent(s)
T=-78°C; 1 h; Title compound not separated from byproducts;
参考文献
Mizuta, Shinya; Ohtsubo, Yutaka; Tsuzuki, Takeo; Fujimoto, Tetsuya; Yamamoto, Iwao
Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8227 - 8229
反应条件
Boc-L-(π-Me)-His-(A)Gly-L-Cha-L-Phe-OMe; diisopropyl-carbodiimide in toluene
T=0°C; Steglich esterification; 10 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Hrdina, Radim; Mueller, Christian E.; Schreiner, Peter R.
Chemical Communications, 2010 , vol. 46, # 15 p. 2689 - 2690
反应条件
2,3-butanediol dehydrogenase from Bacillus subtilis in aq. buffer
T=30°C; pH=8; 4 h; Enzymatic reaction; Reagent/catalyst; enantioselective reaction;
参考文献
Zhang, Jiandong; Xu, Tingting; Li, Zhi
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 16 p. 3147 - 3153
参考文献
Montedison S.p.A.
Patent: US4562299 A1, 1985 ;
反应条件
water in acetonitrile
T=37°C; Enzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Zheng, Huabao; Reetz, Manfred T.
Journal of the American Chemical Society, 2010 , vol. 132, # 44 p. 15744 - 15751
反应条件
cyclic dioldehydrogenase from Rhodococcus sp. Moj-3449 in aq. buffer
T=30°C; pH=8; 8 h; Enzymatic reaction; enantioselective reaction;
参考文献
Zhang, Jiandong; Xu, Tingting; Li, Zhi
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 16 p. 3147 - 3153
